AAGAB and HEATR1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		AAGAB	HEATR1
Description		alpha and gamma adaptin binding protein	HEAT repeat containing 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Speck	Fibrillar Center Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane 90S Preribosome Small-subunit Processome T-UTP Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding	RNA Binding Protein Binding SnoRNA Binding
	Biological Process	Protein Transport	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Positive Regulation Of Transcription By RNA Polymerase I Neural Precursor Cell Proliferation Protein Localization To Nucleolus Positive Regulation Of RRNA Processing
Pathways			rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		A body shape index ( 34021172) Allergic rhinitis ( 30013184) Asthma ( 31619474 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bipolar disorder ( 31043756) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Keratoconus ( 33649486) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Proportion of activated microglia (midfrontal cortex) ( 30679421) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Post bronchodilator FEV1/FVC ratio ( 26634245) Total cholesterol levels ( 30275531)
Interacting Genes		4 interacting genes: AP2S1 EIF3C HEATR1 UNC119	4 interacting genes: AAGAB RNF10 VPS52 XRN1
Entrez ID		79719	55127
HPRD ID		07754	10962
Ensembl ID		ENSG00000103591	ENSG00000119285
Uniprot IDs		Q6PD74	A2VDI1 B2RWN5 Q9H583
PDB IDs		7TWD	7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Pigment Granule Localization Establishment Of Melanosome Localization Regulation Of Response To Food Microtubule Anchoring At Centrosome Pericentriolar Material Sensory Perception Sperm Flagellum Assembly Regulation Of Cilium Beat Frequency Mitotic Cytokinesis Visual Perception Protein Localization To Non-motile Cilium BBSome Maintenance Of Protein Location In Nucleus Intracellular Protein Localization Photoreceptor Cell Outer Segment Organization Retinal Rod Cell Development Negative Regulation Of Appetite Melanosome Localization Protein Transport Response To Leptin Establishment Of Protein Localization Protein Localization To Photoreceptor Outer Segment Brain Morphogenesis Microtubule Anchoring Cytoskeleton-dependent Cytokinesis Striatum Development Fat Pad Development Sensory Perception Of Light Stimulus Erythrocyte Homeostasis Melanosome Transport Leptin-mediated Signaling Pathway Ventricular System Development Face Development Sensory Processing Pigment Granule Transport Dynactin Binding Regulation Of Non-motile Cilium Assembly Retina Homeostasis Protein Localization To Centrosome Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Microtubule Anchoring At Microtubule Organizing Center Regulation Of Appetite Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Negative Regulation Of Systemic Arterial Blood Pressure Clathrin Adaptor Activity Postsynaptic Neurotransmitter Receptor Internalization AP-2 Adaptor Complex Endolysosome Membrane Endocytosis Regulation Of Endocytosis	Embryonic Ectodermal Digestive Tract Development Cellular Response To Puromycin Cellular Response To Cycloheximide GARP Complex EARP Complex Ectodermal Cell Differentiation Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Response To Cycloheximide 5'-3' RNA Exonuclease Activity Vesicle-mediated Cholesterol Transport Protein Transport Golgi Vesicle Transport Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation G-quadruplex RNA Binding G-quadruplex DNA Binding 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Establishment Of Protein Localization Histone MRNA Catabolic Process Golgi To Vacuole Transport Embryonic Digestive Tract Development Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation RRNA Catabolic Process Intracellular Cholesterol Transport Negative Regulation Of Telomere Maintenance Via Telomerase Telomerase RNA Binding Intracellular Sterol Transport Histone MRNA Metabolic Process
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