AAGAB and AP2S1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		AAGAB	AP2S1
Description		alpha and gamma adaptin binding protein	adaptor related protein complex 2 subunit sigma 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Speck	Cytosol Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Endolysosome Membrane Intracellular Membrane-bounded Organelle Synapse Clathrin-coated Endocytic Vesicle Presynapse Postsynapse
	Molecular Function	Protein Binding	Protein Binding Clathrin Adaptor Activity
	Biological Process	Protein Transport	Intracellular Protein Transport Endocytosis Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Clathrin Coat Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization
Pathways			Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		A body shape index ( 34021172) Allergic rhinitis ( 30013184) Asthma ( 31619474 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bipolar disorder ( 31043756) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Keratoconus ( 33649486) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Proportion of activated microglia (midfrontal cortex) ( 30679421) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Brain morphology (MOSTest) ( 32665545) Deep white matter hyperintensities ( 32517579) Low density lipoprotein cholesterol levels ( 32154731) Spondylosis ( 33332786)
Interacting Genes		4 interacting genes: AP2S1 EIF3C HEATR1 UNC119	6 interacting genes: AAGAB AP2A1 AP2B1 CRIPTO RNF41 UBC
Entrez ID		79719	1175
HPRD ID		07754	03762
Ensembl ID		ENSG00000103591	ENSG00000042753
Uniprot IDs		Q6PD74	M0QYZ2 M0R0N4 P53680 X6R390
PDB IDs		7TWD	6URI
Enriched GO Terms of Interacting Partners?		Pigment Granule Localization Establishment Of Melanosome Localization Regulation Of Response To Food Microtubule Anchoring At Centrosome Pericentriolar Material Sensory Perception Sperm Flagellum Assembly Regulation Of Cilium Beat Frequency Mitotic Cytokinesis Visual Perception Protein Localization To Non-motile Cilium BBSome Maintenance Of Protein Location In Nucleus Intracellular Protein Localization Photoreceptor Cell Outer Segment Organization Retinal Rod Cell Development Negative Regulation Of Appetite Melanosome Localization Protein Transport Response To Leptin Establishment Of Protein Localization Protein Localization To Photoreceptor Outer Segment Brain Morphogenesis Microtubule Anchoring Cytoskeleton-dependent Cytokinesis Striatum Development Fat Pad Development Sensory Perception Of Light Stimulus Erythrocyte Homeostasis Melanosome Transport Leptin-mediated Signaling Pathway Ventricular System Development Face Development Sensory Processing Pigment Granule Transport Dynactin Binding Regulation Of Non-motile Cilium Assembly Retina Homeostasis Protein Localization To Centrosome Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Microtubule Anchoring At Microtubule Organizing Center Regulation Of Appetite Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Negative Regulation Of Systemic Arterial Blood Pressure Clathrin Adaptor Activity Postsynaptic Neurotransmitter Receptor Internalization AP-2 Adaptor Complex Endolysosome Membrane Endocytosis Regulation Of Endocytosis	Endocytic Vesicle Membrane Postsynaptic Neurotransmitter Receptor Internalization Postsynaptic Endocytic Zone AP-2 Adaptor Complex Clathrin Adaptor Complex Clathrin Adaptor Activity Endolysosome Membrane Clathrin-coated Endocytic Vesicle Membrane Coat Clathrin-dependent Endocytosis Synaptic Vesicle Endocytosis Presynaptic Endocytosis Receptor Internalization Clathrin-coated Endocytic Vesicle Membrane Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Vesicle-mediated Transport In Synapse Cytoplasmic Side Of Plasma Membrane Interleukin-3 Receptor Binding Synaptic Vesicle Nodal Binding Erythropoietin Receptor Binding Blood Vessel Development Positive Regulation Of Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Signal Sequence Binding Receptor-mediated Endocytosis Extrinsic Component Of Presynaptic Endocytic Zone Membrane Clathrin Coat Activin Receptor Binding Clathrin Coat Of Trans-Golgi Network Vesicle Regulation Of Hyaluronan Biosynthetic Process Heart Development Anterior/posterior Axis Specification, Embryo Protein Transport Nodal Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Endocytosis Golgi To Endosome Transport Cellular Response To Hepatocyte Growth Factor Stimulus Protein Tag Activity Response To Hepatocyte Growth Factor Cellular Response To Interleukin-6 Filopodium Tip Protein-containing Complex Binding Apical Plasma Membrane Establishment Of Protein Localization Clathrin Coat Assembly Response To Interleukin-6 Endoplasmic Reticulum Tubular Network
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