TRRAP and PYGO2

Number of citations of the paper that reports this interaction (PubMedID 20937768)
62

Data Source:
BioGRID (pull down)

		TRRAP	PYGO2
Description		transformation/transcription domain associated protein	pygopus family PHD finger 2
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GO Annotations	Cellular Component	SAGA Complex Nucleosome Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus Transcription Factor TFTC Complex NuA4 Histone Acetyltransferase Complex	Nucleus Nucleoplasm Beta-catenin-TCF Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Kinase Activity	Chromatin Binding Protein Binding Zinc Ion Binding Histone Acetyltransferase Regulator Activity Histone Binding Metal Ion Binding
	Biological Process	Regulation Of DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Process Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Regulation Of Cellular Response To Stress DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Kidney Development Lens Development In Camera-type Eye Spermatid Development Spermatid Nucleus Differentiation Brain Development Wnt Signaling Pathway Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Developmental Growth Roof Of Mouth Development Canonical Wnt Signaling Pathway
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones Ub-specific processing proteases	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)
Interacting Genes		21 interacting genes: ACTL6A ATXN7 AURKA BRCA1 BRD8 CDC42 CEBPA CTNNB1 E2F1 E2F4 EP400 ESR1 HSF1 KAT2A MAX MRGBP MYC NANOG PYGO2 SKP1 TCF3	7 interacting genes: AKT1 BCL9 DCAF1 KAT2A NF2 SUPT3H TRRAP
Entrez ID		8295	90780
HPRD ID		04310	06065
Ensembl ID		ENSG00000196367	ENSG00000163348
Uniprot IDs		H0Y4W2 Q9Y4A5	Q5T170 Q9BRQ0
PDB IDs		7KTR 8H7G 8QRI 8XVG 8XVV 9C47	2XB1 4UP0 4UP5 8HIB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Cellular Response To Stress Euchromatin Regulation Of RNA Metabolic Process Protein-containing Complex Nucleus RNA Polymerase II Transcription Regulator Complex Chromatin Regulation Of Apoptotic Process NuA4 Histone Acetyltransferase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death DNA-binding Transcription Factor Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Transcription Cis-regulatory Region Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair Cellular Response To Xenobiotic Stimulus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding	Transcription Factor TFTC Complex SAGA Complex Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Nerve Growth Factor Regulation Of Organelle Assembly Positive Regulation Of DNA-templated Transcription Cellular Response To Nerve Growth Factor Stimulus Transcription Coactivator Activity Regulation Of DNA Repair Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Striated Muscle Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of TRNA Methylation Regulation Of Cell Cycle Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Tumor Necrosis Factor Nucleoplasm Muscle Cell Differentiation Negative Regulation Of Protein Localization To Lysosome Histone H3K9 Acetyltransferase Activity Carbohydrate Biosynthetic Process Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Response To Tumor Necrosis Factor Cellular Response To Rapamycin Glucose Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Nucleus
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