TRRAP and PYGO2

Number of citations of the paper that reports this interaction (PMID 20937768)
10

Data Source:
BioGRID (pull down)

		TRRAP	PYGO2
Gene Name		transformation/transcription domain-associated protein	pygopus family PHD finger 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	PCAF Complex Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus STAGA Complex Transcription Factor TFTC Complex NuA4 Histone Acetyltransferase Complex	Nucleoplasm
	Molecular Function	Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding Kinase Activity Phosphotransferase Activity, Alcohol Group As Acceptor	Chromatin Binding Protein Binding Zinc Ion Binding Histone Acetyltransferase Regulator Activity Histone Binding
	Biological Process	DNA Repair Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Checkpoint Phosphorylation Histone Acetylation Histone Deubiquitination Histone H4 Acetylation Histone H2A Acetylation	In Utero Embryonic Development Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Post-embryonic Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Palate Development Canonical Wnt Signaling Pathway
Pathways		Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer HATs acetylate histones	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		16 interactors: ACTL6A ATXN7 BRCA1 BRD8 CTNNB1 E2F1 E2F4 EP400 ESR1 KAT2A MAX MRGBP MYC PYGO2 SKP1 TCF3	5 interactors: BCL9 KAT2A NF2 SUPT3H TRRAP
Entrez ID		8295	90780
HPRD ID		04310	06065
Ensembl ID		ENSG00000196367	ENSG00000163348
Uniprot IDs		Q9Y4A5	Q5T170 Q9BRQ0
PDB IDs			2XB1
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Organelle Organization Chromosome Organization Histone H4 Acetylation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Histone Acetylation Macromolecule Biosynthetic Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H2A Acetylation Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone H3-K4 Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Canonical Wnt Signaling Pathway Regulation Of Fibroblast Proliferation Cellular Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cell Proliferation Organ Development Cellular Response To Indole-3-methanol Regulation Of Histone Methylation Tissue Development Chromatin Remodeling Regulation Of Chromosome Organization	Histone Deubiquitination Protein Deubiquitination Histone Acetylation Internal Peptidyl-lysine Acetylation Protein Modification By Small Protein Removal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Peptidyl-lysine Modification Histone H3 Acetylation Histone Modification Histone H4 Acetylation Chromatin Modification Chromatin Organization Regulation Of Protein Stability Regulation Of Gene Expression Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromosome Organization Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Histone H3-K14 Acetylation Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Schwann Cell Proliferation Telencephalon Development Organelle Organization Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Hippo Signaling Histone H4-K12 Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Histone H2A Acetylation Glial Cell Proliferation Regulation Of Metabolic Process Forebrain Development Tissue Development Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Gluconeogenesis Growth Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of JAK-STAT Cascade Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Ectoderm Development
Tagcloud ?		arid1a ash1l atlas broadly chd6 colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta uncertain validating	catenin compartment converge depilation dispensable emerged epithelia excessive facilitates follicle hair holds homeobox homolog hyperactivation hyperplasia keratinocytes lhx2 lim maximizes prime progenitor prominent promise pygopus regeneration stem trichofolliculoma wnt
Tagcloud (Difference) ?		arid1a ash1l atlas broadly chd6 colorectal concordant copy ep300 ep400 exome gains hypermutation mismatch mll2 mll3 nonhypermutated prdm2 preexisting profiled proofreading resembled seq signatures silico srcap tgfbeta uncertain validating	catenin compartment converge depilation dispensable emerged epithelia excessive facilitates follicle hair holds homeobox homolog hyperactivation hyperplasia keratinocytes lhx2 lim maximizes prime progenitor prominent promise pygopus regeneration stem trichofolliculoma wnt
Tagcloud (Intersection) ?