TRRAP and NANOG

Number of citations of the paper that reports this interaction (PubMedID 37047234)
31

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TRRAP	NANOG
Description		transformation/transcription domain associated protein	Nanog homeobox
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GO Annotations	Cellular Component	SAGA Complex Nucleosome Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus Transcription Factor TFTC Complex NuA4 Histone Acetyltransferase Complex	Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	Transcription Coregulator Activity Protein Binding Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Apoptotic Process Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Regulation Of Cellular Response To Stress DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Stem Cell Population Maintenance Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Stem Cell Proliferation
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones Ub-specific processing proteases	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Germ layer formation at gastrulation Formation of the anterior neural plate Specification of primordial germ cells
Drugs
Diseases
GWAS		Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		21 interacting genes: ACTL6A ATXN7 AURKA BRCA1 BRD8 CDC42 CEBPA CTNNB1 E2F1 E2F4 EP400 ESR1 HSF1 KAT2A MAX MRGBP MYC NANOG PYGO2 SKP1 TCF3	8 interacting genes: BRAF MED12 PRKCE RBPMS RHOXF2 SPOP TRRAP USP21
Entrez ID		8295	79923
HPRD ID		04310	06397
Ensembl ID		ENSG00000196367	ENSG00000111704
Uniprot IDs		H0Y4W2 Q9Y4A5	A8K4D1 Q9H9S0
PDB IDs		7KTR 8H7G 8QRI 8XVG 8XVV 9C47	2KT0 4RBO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Binding Regulation Of Cellular Response To Stress Euchromatin Regulation Of RNA Metabolic Process Protein-containing Complex Nucleus RNA Polymerase II Transcription Regulator Complex Chromatin Regulation Of Apoptotic Process NuA4 Histone Acetyltransferase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death DNA-binding Transcription Factor Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Transcription Regulator Complex Transcription Cis-regulatory Region Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair Cellular Response To Xenobiotic Stimulus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding	Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Fibroblast Migration Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Protein Modification Process Positive Regulation Of Biosynthetic Process Nucleus Somatic Stem Cell Population Maintenance Positive Regulation Of Macromolecule Metabolic Process Ethanol Binding Axis Elongation Involved In Somitogenesis Maintenance Of Cell Number Stem Cell Population Maintenance Positive Regulation Of Cell-substrate Adhesion TRAM-dependent Toll-like Receptor 4 Signaling Pathway Transcription Coregulator Activity
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