HNRNPH1 and MIR140

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		HNRNPH1	MIR140
Description		heterogeneous nuclear ribonucleoprotein H1	microRNA 140
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Extracellular Space RISC Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Poly(U) RNA Binding Identical Protein Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing Regulation Of RNA Splicing	Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Defense Response To Bacterium Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Osteoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Vascular Endothelial Growth Factor Production Cellular Response To Amyloid-beta Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs		Copper
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Body mass index ( 26426971)
Interacting Genes		136 interacting genes: APBB1 ARHGEF16 CASP7 CATSPER1 CCDC120 CCNK CRMP1 DDX17 DUX4 DZIP3 ENKD1 ERG FOXP1 GPANK1 GPS2 HIPK3 HNRNPF HNRNPH3 HNRNPM KHSRP KRTAP13-2 LMO1 LMO3 LNX1 MAGED1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL53 MSI2 MTNR1A MYPOP NCBP1 NCBP2 NDRG1 NFKBID NUDT16L1 OGT OXER1 PATZ1 PCAT1 PEX5 PIN1 POLR1C RALY RAMAC RBFOX2 RBM38 RNF10 RNF4 SAXO4 SF1 SF3B4 SNRPB SNRPC SPG21 SREK1 SUMO2 SUMO4 TCERG1 TEKT3 TEKT4 TOM1L1 WEE2-AS1 YPEL3 YWHAG YWHAQ	68 interacting genes: ADARB1 AIMP1 APOBEC3B C1QBP CELF1 CELF2 CRTAP CSTF1 DARS1 DDX1 DDX21 DDX3X DDX49 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 PDCD11 PIKFYVE PIP5K1A PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RTCB SF3B1 SF3B3 SFPQ SYNCRIP TAF15 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3
Entrez ID		3187	406932
HPRD ID		03021
Ensembl ID		ENSG00000169045	ENSG00000208017
Uniprot IDs		A0A384MEJ3 A0A9L9PY23 A0AAG2UWX3 E9PCY7 G8JLB6 H0YBD7 P31943
PDB IDs		2LXU 6DHS 7ZUG
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Locomotion Regulation Of Translation Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of MRNA Stability Negative Regulation Of Cytokine Production Regulation Of RNA Stability Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing MRNA Binding Macromolecule Metabolic Process Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome Nucleus RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of MRNA Splicing, Via Spliceosome Nucleoplasm Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Processing Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Spliceosomal Complex Regulation Of Gene Expression Catalytic Step 2 Spliceosome Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Regulation Of Primary Metabolic Process Regulation Of Translation Regulation Of Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of RNA Catabolic Process MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability RNA Stabilization Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process MiRNA Binding TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Translation Regulation Of Nucleobase-containing Compound Metabolic Process TRNA Aminoacylation Nucleolus
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