HNRNPH1 and NCBP2

Number of citations of the paper that reports this interaction (PubMedID 9111328)
62

Data Source:
HPRD (in vitro)

		HNRNPH1	NCBP2
Description		heterogeneous nuclear ribonucleoprotein H1	nuclear cap binding protein subunit 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Membrane Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Cap Binding Complex RNA Cap Binding Complex Ciliary Basal Body
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Poly(U) RNA Binding Identical Protein Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding SnRNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing Regulation Of RNA Splicing	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Cap-dependent Translational Initiation MRNA Processing MRNA Export From Nucleus SnRNA Export From Nucleus Regulation Of Translation Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing MRNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Transcription By RNA Polymerase II MRNA Cis Splicing, Via Spliceosome Positive Regulation Of RNA Export From Nucleus MRNA Transport
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay
Drugs		Copper
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Malaria ( 31844061) Night sleep phenotypes ( 27126917) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		136 interacting genes: APBB1 ARHGEF16 CASP7 CATSPER1 CCDC120 CCNK CRMP1 DDX17 DUX4 DZIP3 ENKD1 ERG FOXP1 GPANK1 GPS2 HIPK3 HNRNPF HNRNPH3 HNRNPM KHSRP KRTAP13-2 LMO1 LMO3 LNX1 MAGED1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL53 MSI2 MTNR1A MYPOP NCBP1 NCBP2 NDRG1 NFKBID NUDT16L1 OGT OXER1 PATZ1 PCAT1 PEX5 PIN1 POLR1C RALY RAMAC RBFOX2 RBM38 RNF10 RNF4 SAXO4 SF1 SF3B4 SNRPB SNRPC SPG21 SREK1 SUMO2 SUMO4 TCERG1 TEKT3 TEKT4 TOM1L1 WEE2-AS1 YPEL3 YWHAG YWHAQ	7 interacting genes: DDX39B EIF4G1 EIF5 HNRNPF HNRNPH1 LZTS2 NCBP1
Entrez ID		3187	22916
HPRD ID		03021	05503
Ensembl ID		ENSG00000169045	ENSG00000114503
Uniprot IDs		A0A384MEJ3 A0A9L9PY23 A0AAG2UWX3 E9PCY7 G8JLB6 H0YBD7 P31943	F6WVI0 P52298
PDB IDs		2LXU 6DHS 7ZUG	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY 5OO6 5OOB 6D0Y 7ABG 8BY6 8PMP 8PNT 8SRR 8SUY
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Locomotion Regulation Of Translation Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of MRNA Stability Negative Regulation Of Cytokine Production Regulation Of RNA Stability Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cap-dependent Translational Initiation RNA Binding Translational Initiation RNA Splicing Regulation Of Translational Initiation MRNA Processing Nuclear Export Spliceosomal Complex Regulation Of RNA Splicing Protein-RNA Complex Assembly MRNA Metabolic Process Cytoplasmic Translational Initiation MRNA Binding Nuclear Transport Nucleocytoplasmic Transport Spliceosomal Complex Assembly Translation Initiation Factor Activity RNA Processing MRNA Export From Nucleus Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Ribonucleoprotein Complex Positive Regulation Of RNA Binding Primary Ureteric Bud Growth Regulation Of Translation RNA Export From Nucleus Catalytic Step 2 Spliceosome MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Eukaryotic Initiation Factor EIF2 Binding Nucleic Acid Binding RNA Metabolic Process RNA Cap Binding Complex MRNA Transport Nuclear Cap Binding Complex Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression SnRNA Export From Nucleus RNA Transport Positive Regulation Of Cell Growth Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of MRNA 3'-end Processing Molecular Adaptor Activity Macromolecule Metabolic Process Positive Regulation Of Translation In Response To Stress 7-methylguanosine MRNA Capping ATP-dependent Protein Binding U4 SnRNA Binding
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