YARS and ELANE

Number of citations of the paper that reports this interaction (PMID 10102815)
85

Data Source:
HPRD (in vitro)

		YARS	ELANE
Gene Name		tyrosyl-tRNA synthetase	elastase, neutrophil expressed
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	TRNA Binding Isoleucine-tRNA Ligase Activity Tyrosine-tRNA Ligase Activity Signal Transducer Activity Interleukin-8 Receptor Binding ATP Binding Poly(A) RNA Binding	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Isoleucyl-tRNA Aminoacylation Tyrosyl-tRNA Aminoacylation Apoptotic Process Signal Transduction Gene Expression	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		L-Tyrosine Beta-(2-Naphthyl)-Alanine Tyrosinal N6-ISOPENTENYL-ADENOSINE-5\'-MONOPHOSPHATE PARA-(BENZOYL)-PHENYLALANINE 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE	Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ELANE	30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS
Entrez ID		8565	1991
HPRD ID		09153	00554
Ensembl ID		ENSG00000134684	ENSG00000197561
Uniprot IDs		P54577	P08246
PDB IDs		1N3L 1NTG 1Q11	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77
Enriched GO Terms of Interacting Partners?		Neutrophil Mediated Killing Of Fungus Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Positive Regulation Of Interleukin-8 Biosynthetic Process Killing By Host Of Symbiont Cells Acute Inflammatory Response To Antigenic Stimulus Regulation Of Interleukin-8 Biosynthetic Process Negative Regulation Of Interleukin-8 Production Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemotaxis Defense Response To Fungus Positive Regulation Of Interleukin-8 Production Interaction With Symbiont Leukocyte Mediated Cytotoxicity Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Regulation Of Chemokine Production Positive Regulation Of Smooth Muscle Cell Proliferation Collagen Catabolic Process Positive Regulation Of Cytokine Biosynthetic Process Acute Inflammatory Response Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Cytokine Biosynthetic Process Response To UV Regulation Of Chemotaxis Regulation Of Behavior Defense Response To Bacterium Negative Regulation Of Cytokine Production Positive Regulation Of MAP Kinase Activity Leukocyte Migration Negative Regulation Of Growth Negative Regulation Of Locomotion Phagocytosis Leukocyte Mediated Immunity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Inflammatory Response Regulation Of MAP Kinase Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation
Tagcloud ?		abnormal accordingly anergy ciita class classical constitutive deregulation displaying dissemination dr escape fibroblast histocompatibility hla isoform lymphocyte melanocytes melanoma melanomas mhc participate synthetase transactivator transforming trip1 trna tumour tyrosyl	absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Difference) ?		abnormal accordingly anergy ciita class classical constitutive deregulation displaying dissemination dr escape fibroblast histocompatibility hla isoform lymphocyte melanocytes melanoma melanomas mhc participate synthetase transactivator transforming trip1 trna tumour tyrosyl	absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Intersection) ?