YARS1

Name	tyrosyl-tRNA synthetase 1
Structure
Interactors	6 interactors: CDC42 ELANE ESR1 OGT REL USP25
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Nuclear Body
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Tyrosine-tRNA Ligase Activity Interleukin-8 Receptor Binding Protein Binding ATP Binding Ligase Activity Small Molecule Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Tyrosyl-tRNA Aminoacylation Apoptotic Process Response To Stress Response To Starvation Protein Poly-ADP-ribosylation
Pathways	Cytosolic tRNA aminoacylation
Drugs	Tyrosine Beta-(2-Naphthyl)-Alanine Resveratrol Tyrosinal N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE p-Benzoyl-L-phenylalanine 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE
Diseases	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS	No GWAS studies recorded
Entrez ID	8565
HPRD ID	09153
Ensembl ID	ENSG00000134684
Uniprot IDs	A0A0S2Z4R1 P54577
PDB IDs	1N3L 1NTG 1Q11 4Q93 4QBT 5THH 5THL 7ROU
GO Terms Enriched among Interactors ?	Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Pyroptotic Inflammatory Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phagocytic Vesicle Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Negative Regulation Of Gene Expression ATPase Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Negative Regulation Of Protein-containing Complex Assembly Storage Vacuole Cytosol Antibacterial Peptide Biosynthetic Process Negative Regulation Of Metabolic Process Inflammatory Response Neutrophil-mediated Killing Of Fungus Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Negative Regulation Of Interleukin-17-mediated Signaling Pathway Apolipoprotein A-I Receptor Binding Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Neuropilin Signaling Pathway Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth NF-kappaB Complex Protein-containing Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Ubiquitin-like Protein Peptidase Activity Non-canonical Inflammasome Complex Assembly Regulation Of Proteasomal Protein Catabolic Process