MSTN and TCAP

Number of citations of the paper that reports this interaction (PubMedID 12209887)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MSTN	TCAP
Description		myostatin	titin-cap
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Cytosol Sarcomere Z Disc I Band Titin-telethonin Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity	Protein Binding Structural Constituent Of Muscle Protein-macromolecule Adaptor Activity Titin Binding BMP Binding Transmembrane Transporter Binding FATZ Binding Molecular Adaptor Activity Titin Z Domain Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Skeletal Muscle Tissue Development Response To Gravity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macrophage Chemotaxis Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Skeletal Muscle Satellite Cell Differentiation Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Skeletal Muscle Tissue Regeneration Response To Estrogen Response To Ethanol Negative Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Negative Regulation Of Skeletal Muscle Tissue Growth Response To Glucocorticoid Response To Electrical Stimulus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Trophoblast Cell Migration Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation	Somitogenesis Skeletal Muscle Contraction Cardiac Muscle Hypertrophy Adult Heart Development Animal Organ Morphogenesis Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Otic Vesicle Formation Response To Muscle Stretch Detection Of Muscle Stretch Sarcomere Organization Anatomical Structure Formation Involved In Morphogenesis Tissue Morphogenesis Sarcomerogenesis Detection Of Mechanical Stimulus Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly
Pathways		FOXO-mediated transcription of cell cycle genes	Striated Muscle Contraction
Drugs		Stamulumab
Diseases			Limb-girdle muscular dystrophy (LGMD)
GWAS		Daytime sleep phenotypes ( 27126917) Schizophrenia ( 34099189)	Alcohol consumption ( 31358974) Asthma ( 31619474 31959851) Asthma or allergic disease (pleiotropy) ( 29785011) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Ulcerative colitis ( 20228799)
Interacting Genes		6 interacting genes: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2	38 interacting genes: ACTMAP ADPGK ANKRD2 ASB6 ATXN1 BLZF1 CDCA4 CHORDC1 CRK ENO1 ENO3 FAM153B FAS FYN GSK3B HSPB2 HSPB3 HSPG2 IKZF3 KLHL41 KRTAP19-7 LAMTOR5 LHX4 MDM2 MSTN MYOZ1 MYOZ3 NUP133 PAX7 PDPK1 RELA SAPCD1 SIVA1 TRIM54 TRIM55 TRIM63 TTC19 TTN
Entrez ID		2660	8557
HPRD ID		03474	05133
Ensembl ID		ENSG00000138379	ENSG00000173991
Uniprot IDs		O14793 Q53S46	A2TDC0 O15273
PDB IDs		5F3B 5F3H 5NTU 5NXS 6UMX	1YA5 2F8V
Enriched GO Terms of Interacting Partners?		Activin Binding Regulation Of Activin Receptor Signaling Pathway Roof Of Mouth Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization TRC Complex Titin-telethonin Complex Titin Z Domain Binding Muscle Cell Development Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Anterior/posterior Pattern Specification Venous Blood Vessel Development Activin Receptor Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling BAT3 Complex Binding Myosin Filament Assembly FATZ Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway	Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process M Band Telethonin Binding Actinin Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Glycolytic Process Through Glucose-6-phosphate Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Glycolytic Process Through Fructose-6-phosphate Regulation Of Myoblast Proliferation Z Disc Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization Skeletal Muscle Atrophy Myofibril Assembly FATZ Binding Response To Hydrogen Peroxide Activation-induced Cell Death Of T Cells Diapedesis Cellular Response To Hormone Stimulus Skeletal Muscle Adaptation Striated Muscle Atrophy Extrinsic Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway Glycolytic Process Muscle Atrophy Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway ADP Catabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Enzyme Binding Purine Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Intracellular Signal Transduction Muscle System Process Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Phospholipase Activator Activity Nucleoside Diphosphate Catabolic Process Muscle Structure Development Reelin-mediated Signaling Pathway Skeletal Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Hormone Response To Reactive Oxygen Species Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Developmental Process Pyruvate Metabolic Process
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