MSTN and WFIKKN2

Number of citations of the paper that reports this interaction (PubMedID 12595574)
0

Data Source:
HPRD (in vitro)

		MSTN	WFIKKN2
Description		myostatin	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity	Enzyme Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Receptor Antagonist Activity Transforming Growth Factor Beta Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Skeletal Muscle Tissue Development Response To Gravity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macrophage Chemotaxis Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Skeletal Muscle Satellite Cell Differentiation Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Skeletal Muscle Tissue Regeneration Response To Estrogen Response To Ethanol Negative Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Negative Regulation Of Skeletal Muscle Tissue Growth Response To Glucocorticoid Response To Electrical Stimulus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Trophoblast Cell Migration Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation	Skeletal System Development Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Cell Development Roof Of Mouth Development
Pathways		FOXO-mediated transcription of cell cycle genes
Drugs		Stamulumab
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Schizophrenia ( 34099189)	Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Diverticular disease ( 30177863)
Interacting Genes		6 interacting genes: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2	1 interacting genes: MSTN
Entrez ID		2660	124857
HPRD ID		03474	18303
Ensembl ID		ENSG00000138379	ENSG00000173714
Uniprot IDs		O14793 Q53S46	C9J6G4 Q8TEU8
PDB IDs		5F3B 5F3H 5NTU 5NXS 6UMX
Enriched GO Terms of Interacting Partners?		Activin Binding Regulation Of Activin Receptor Signaling Pathway Roof Of Mouth Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization TRC Complex Titin-telethonin Complex Titin Z Domain Binding Muscle Cell Development Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Anterior/posterior Pattern Specification Venous Blood Vessel Development Activin Receptor Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling BAT3 Complex Binding Myosin Filament Assembly FATZ Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway	Negative Regulation Of Skeletal Muscle Cell Differentiation Myoblast Migration Involved In Skeletal Muscle Regeneration Negative Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Response To Gravity Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Myoblast Proliferation Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Negative Regulation Of Skeletal Muscle Tissue Growth Trophoblast Cell Migration Skeletal Muscle Satellite Cell Differentiation Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Myoblast Migration Regulation Of Skeletal Muscle Cell Proliferation Muscle Cell Cellular Homeostasis Cellular Response To Dexamethasone Stimulus Positive Regulation Of Lamellipodium Assembly Regulation Of Skeletal Muscle Cell Differentiation Positive Regulation Of Macrophage Migration Skeletal Muscle Tissue Regeneration Positive Regulation Of Macrophage Chemotaxis Regulation Of Myoblast Proliferation Regulation Of Macrophage Chemotaxis Negative Regulation Of Myoblast Differentiation Muscle Cell Migration Response To Muscle Activity Positive Regulation Of Lamellipodium Organization Ovulation Cycle Process Response To Electrical Stimulus Negative Regulation Of Muscle Hypertrophy Response To Testosterone Regulation Of Lamellipodium Assembly Response To Dexamethasone Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of Macrophage Migration Regulation Of Lamellipodium Organization Regulation Of Granulocyte Chemotaxis Negative Regulation Of Insulin Receptor Signaling Pathway Tissue Regeneration Cellular Response To Glucocorticoid Stimulus Skeletal Muscle Cell Differentiation Response To Estrogen Skeletal Muscle Tissue Development Cellular Response To Corticosteroid Stimulus Regulation Of Myoblast Differentiation Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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