MSTN and ACVR2B

Number of citations of the paper that reports this interaction (PubMedID 11459935)
33

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		MSTN	ACVR2B
Description		myostatin	activin A receptor type 2B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Skeletal Muscle Tissue Development Response To Gravity Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Macrophage Chemotaxis Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Skeletal Muscle Satellite Cell Differentiation Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Skeletal Muscle Tissue Regeneration Response To Estrogen Response To Ethanol Negative Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Negative Regulation Of Skeletal Muscle Tissue Growth Response To Glucocorticoid Response To Electrical Stimulus Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Trophoblast Cell Migration Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development
Pathways		FOXO-mediated transcription of cell cycle genes	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs		Stamulumab
Diseases			Heterotaxy; Situs ambiguus
GWAS		Daytime sleep phenotypes ( 27126917) Schizophrenia ( 34099189)	Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462 31152163) P wave duration ( 24850809)
Interacting Genes		6 interacting genes: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2	26 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1
Entrez ID		2660	93
HPRD ID		03474	04106
Ensembl ID		ENSG00000138379	ENSG00000114739
Uniprot IDs		O14793 Q53S46	Q13705
PDB IDs		5F3B 5F3H 5NTU 5NXS 6UMX	2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY
Enriched GO Terms of Interacting Partners?		Activin Binding Regulation Of Activin Receptor Signaling Pathway Roof Of Mouth Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Peptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization TRC Complex Titin-telethonin Complex Titin Z Domain Binding Muscle Cell Development Skeletal Muscle Myosin Thick Filament Assembly Sarcomerogenesis Anterior/posterior Pattern Specification Venous Blood Vessel Development Activin Receptor Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling BAT3 Complex Binding Myosin Filament Assembly FATZ Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation
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