MSTN and ACVR2B

Number of citations of the paper that reports this interaction (PMID 11459935)
195

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MSTN	ACVR2B
Gene Name		myostatin	activin A receptor, type IIB
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Metal Ion Binding Activin Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Response To Heat Response To Gravity Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of MAPK Cascade Response To Estrogen Response To Ethanol Positive Regulation Of Transcription, DNA-templated Cell Development Negative Regulation Of Skeletal Muscle Tissue Growth Response To Electrical Stimulus SMAD Protein Signal Transduction Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation	Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Signal Transduction By Phosphorylation Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Palate Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye
Pathways			Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2	18 interactors: ACVR1B BMP10 BMP2 BMP7 ERBB2IP GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN SNX1 SNX2 SNX6 SYNJ2BP TGFBRAP1
Entrez ID		2660	93
HPRD ID		03474	04106
Ensembl ID		ENSG00000138379	ENSG00000114739
Uniprot IDs		O14793 Q53S46	Q13705
PDB IDs			2H62 2QLU 4FAO
Enriched GO Terms of Interacting Partners?		Regulation Of Activin Receptor Signaling Pathway Muscle Fiber Development Palate Development Cell Differentiation Synaptic Growth At Neuromuscular Junction Regulation Of Protein Binding Striated Muscle Cell Development Sarcomerogenesis Collateral Sprouting In Absence Of Injury Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Muscle Cell Development System Development Collateral Sprouting Axon Midline Choice Point Recognition Myosin Filament Assembly Striated Muscle Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Multicellular Organismal Development Axon Choice Point Recognition Skeletal Muscle Thin Filament Assembly Lung Development Anterior/posterior Pattern Specification Respiratory Tube Development Regulation Of Binding Negative Regulation Of Endopeptidase Activity Positive Regulation Of Activin Receptor Signaling Pathway Anatomical Structure Development Negative Regulation Of Peptidase Activity Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Lymphatic Endothelial Cell Differentiation Respiratory System Development Neuron Remodeling Negative Regulation Of Activin Receptor Signaling Pathway Kidney Development Muscle Cell Differentiation Otic Vesicle Formation Renal System Development Lymphangiogenesis Organ Development Negative Regulation Of Proteolysis Otic Vesicle Morphogenesis Developmental Process Lymph Vessel Morphogenesis Negative Regulation Of Protein Processing Urogenital System Development Regulation Of Endopeptidase Activity	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Cell Development Negative Regulation Of Cell Proliferation Regulation Of Cell Differentiation Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Growth Tissue Development Positive Regulation Of Cell Differentiation Signaling Cell Communication Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Anatomical Structure Development Regulation Of Growth Negative Regulation Of Cell Growth Lamellipodium Morphogenesis Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Cell Proliferation Cartilage Development Developmental Process
Tagcloud ?		adenoviral adenovirus aforesaid backgrounds conversion decades ectopic electroporation eliminating facilitated fibroblasts fos lentiviral master muscle muscles myoblasts myod myogenesis myogenic myostatin myotubes negligible offers scarcity take transduced transducing wasting	arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Difference) ?		adenoviral adenovirus aforesaid backgrounds conversion decades ectopic electroporation eliminating facilitated fibroblasts fos lentiviral master muscle muscles myoblasts myod myogenesis myogenic myostatin myotubes negligible offers scarcity take transduced transducing wasting	arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Intersection) ?