ITPRIP and PGRMC2

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ITPRIP	PGRMC2
Description		inositol 1,4,5-trisphosphate receptor interacting protein	progesterone receptor membrane component 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Plasma Membrane Membrane	Extracellular Region Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endomembrane System Membrane Synapse Glutamatergic Synapse
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Nuclear Steroid Receptor Activity Steroid Binding Protein Binding Lipid Binding Heme Transmembrane Transporter Activity Heme Binding
	Biological Process	Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Heme Transport Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Adipose Tissue Development
Pathways			RHOA GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Heme signaling
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494)	Bone mineral density (total hip) ( 29883787)
Interacting Genes		5 interacting genes: ITPR1 NLGN3 PGRMC2 RASSF3 SGTB	55 interacting genes: AQP10 ART5 BAG4 C5 COX20 CYB561D2 CYP4F2 DGAT2L6 DHRSX EI24 FA2H FAXDC2 FXYD6 FXYD6-FXYD2 GET3 GHITM GPR151 ITGAM ITPRIP LINC00632 LPAR3 MALL MFHAS1 ORMDL1 PEDS1-UBE2V1 PEX16 PLLP PMP22 RNF8 RUSF1 SFXN1 SLC16A13 SLC30A8 SLC38A1 SLC39A13 SLC9B2 SMPD2 ST6GAL2 STX3 TAS2R19 TECR TF TMEM107 TMEM187 TMEM19 TMEM208 TMEM60 TMEM86A TMEM86B TSPAN2 UBXN8 VEZT YIPF2 ZDHHC21 ZFPL1
Entrez ID		85450	10424
HPRD ID		13892	09665
Ensembl ID		ENSG00000148841	ENSG00000164040
Uniprot IDs		Q8IWB1	O15173
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Protein Homooligomerization Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Epithelial Fluid Transport Platelet Dense Granule Membrane Nuclear Envelope Protein Complex Oligomerization Calcium Ion Transmembrane Transporter Activity Platelet Dense Tubular Network Membrane Synapse Calcium Import Into The Mitochondrion Calcineurin Complex Voluntary Musculoskeletal Movement Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Inositol 1,4,5 Trisphosphate Binding Heme Transmembrane Transporter Activity Heme Transport Neurexin Family Protein Binding Asymmetric, Glutamatergic, Excitatory Synapse Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Rhythmic Synaptic Transmission Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Regulation Of Glutamate Receptor Signaling Pathway Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Presynapse Assembly Presynaptic Membrane Organization Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRC Complex Musculoskeletal Movement Calcium Channel Inhibitor Activity Regulation Of Respiratory System Process Neuron Cell-cell Adhesion Mitochondrial Calcium Ion Transmembrane Transport Presynapse Organization G Protein-coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Calcium-mediated Signaling Vocalization Behavior Nuclear Steroid Receptor Activity Regulation Of Respiratory Gaseous Exchange Endoplasmic Reticulum Calcium Ion Homeostasis Protein Heterooligomerization	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Myelination Axon Ensheathment Alkenylglycerophosphocholine Hydrolase Activity Compact Myelin
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