PRXL2B and TCP11L1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRXL2B	TCP11L1
Description		peroxiredoxin like 2B	t-complex 11 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Myelin Sheath Extracellular Exosome	Microtubule
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Prostaglandin F Synthase Activity	Protein Binding
	Biological Process	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process	Signal Transduction
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs
Diseases
GWAS			Anger ( 24489884) Platelet distribution width ( 32888494)
Interacting Genes		4 interacting genes: COPS3 PDPK1 TCP11L1 TNFSF11	24 interacting genes: APP CNOT7 DDIT4L ERCC6L2 HMG20A IKBKG IPO4 LHX2 MAGEA12 MEOX1 NEDD4 OGT PAX6 PLEKHS1 PRXL2B PSMD4 REL SDCBP2 SNW1 TBX6 TRIM21 TSNAX VPS52 WWTR1
Entrez ID		127281	55346
HPRD ID		14513	07750
Ensembl ID		ENSG00000157870	ENSG00000176148
Uniprot IDs		A0A0A0MRV4 A0A0A0MT35 A0A2P0CTB1 A0A2P0CU24 J3KPF5 Q8TBF2	B3KQZ4 Q9NUJ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion 3-phosphoinositide-dependent Protein Kinase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium-mediated Signaling Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Phospholipase Activator Activity Regulation Of T Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type B Pancreatic Cell Development Positive Regulation Of Cell Activation Regulation Of Canonical NF-kappaB Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Protein Deneddylation Tooth Eruption Positive Regulation Of Osteoclast Development Positive Regulation Of Bone Resorption Positive Regulation Of Fever Generation Osteoclast Development Positive Regulation Of Heat Generation Regulation Of Osteoclast Development Osteoclast Proliferation Paracrine Signaling Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Regulation Of Corticotropin-releasing Hormone Secretion Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of Corticotropin-releasing Hormone Secretion Regulation Of Fever Generation Vascular Endothelial Cell Response To Fluid Shear Stress Signal Transduction Positive Regulation Of Icosanoid Secretion Mammary Gland Alveolus Development Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Cell Adhesion Negative Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Phospholipase Binding Cellular Response To Laminar Fluid Shear Stress Response To Laminar Fluid Shear Stress Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Protein Neddylation Protein Neddylation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Fatty Acid Transport Regulation Of Lymphocyte Activation Monocyte Chemotaxis	Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Telencephalon Regionalization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process HMG Box Domain Binding Regulation Of Neuron Differentiation Transcription Corepressor Activity Positive Regulation Of Metabolic Process Negative Regulation Of Post-translational Protein Modification DNA Binding Sequence-specific DNA Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Chromatin Protein-containing Complex Regulation Of Primary Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catabolic Process Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Formation Of Structure Involved In A Symbiotic Process Forebrain-midbrain Boundary Formation Signal Transduction Involved In Regulation Of Gene Expression
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