KRTAP4-2 and SLC23A1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KRTAP4-2	SLC23A1
Gene Name		keratin associated protein 4-2	solute carrier family 23 (ascorbic acid transporter), member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Keratin Filament	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Basal Plasma Membrane Membrane Apical Plasma Membrane Intracellular Organelle Extracellular Vesicular Exosome
	Molecular Function		Protein Binding L-ascorbate:sodium Symporter Activity Sodium Ion Transmembrane Transporter Activity Nucleobase Transmembrane Transporter Activity L-ascorbic Acid Transporter Activity Dehydroascorbic Acid Transporter Activity Sodium-dependent L-ascorbate Transmembrane Transporter Activity
	Biological Process		Nucleobase-containing Compound Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Sodium Ion Transport Brain Development Response To Toxic Substance Nucleobase Transport L-ascorbic Acid Transport L-ascorbic Acid Metabolic Process Lung Development Vitamin Transmembrane Transport Sodium Ion Transmembrane Transport Small Molecule Metabolic Process Dehydroascorbic Acid Transport Transepithelial L-ascorbic Acid Transport
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs			Vitamin C
Diseases
GWAS
Protein-Protein Interactions		72 interactors: ADAMTSL4 ALDH3B1 AMOTL2 AQP1 ATG9A BYSL C19orf66 CHIC2 CHRD CRCT1 CREB5 DLGAP2 DOCK2 FAM74A4 GLRX3 GNMT HOXA1 HPCAL1 HSD3B7 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP26-1 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1B LCE2A LCE3C LCE3E LCE4A LNX1 MEOX2 NLK NOTCH2NL NR1D2 NUFIP2 OTX1 PDE9A PGLS PIN1 PLSCR1 POM121L8P PRKAB2 PRKAG1 PSMA6 PVRL3 RASSF5 RGS20 SLC23A1 SLC25A10 SPATA24 SPATA3 SPRY1 TCEANC TINAGL1 TRIM42 TXNDC5 TYRO3 WDYHV1 ZBTB24 ZNF124 ZNF20 ZNF417 ZNF559 ZNF581	12 interactors: ADAMTSL4 AHCYL1 KRT31 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 MTUS2 NOTCH2NL
Entrez ID		85291	9963
HPRD ID		13944	04810
Ensembl ID		ENSG00000244537	ENSG00000170482
Uniprot IDs		Q9BYR5	Q9UHI7
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratinization Keratinocyte Differentiation Epidermal Cell Differentiation Epidermis Development Transcription, DNA-templated Epithelium Development Skin Development RNA Biosynthetic Process Organ Development Tissue Development Transepithelial Transport Cellular Process Cellular Nitrogen Compound Metabolic Process Gene Expression Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Multicellular Organismal Development Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Cell Clearance BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Abducens Nerve Formation Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport Optokinetic Behavior Transepithelial L-ascorbic Acid Transport Organic Anion Transport
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