NCKAP1L and GAS7

Number of citations: 76 (PubMedID 16055720)
Data Source: BioGRID (pull down)

		NCKAP1L	GAS7
Name		NCK associated protein 1 like	growth arrest specific 7
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Secretory Granule Membrane SCAR Complex Extracellular Exosome Ficolin-1-rich Granule Membrane	Cytoplasm Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle
	Molecular Function	GTPase Activator Activity Protein Binding Protein Kinase Activator Activity Protein-containing Complex Binding TORC2 Complex Binding	Protein Binding Identical Protein Binding
	Biological Process	Cell Morphogenesis B Cell Homeostasis Myeloid Cell Homeostasis Positive Regulation Of Leukocyte Migration Chemotaxis Response To Xenobiotic Stimulus Cell Migration Maintenance Of Cell Polarity Cell Projection Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Positive Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Erythrocyte Homeostasis Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation T Cell Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Cytotoxic T Cell Degranulation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Neuron Projection Morphogenesis Erythrocyte Development B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Protein-containing Complex Assembly Actin Polymerization-dependent Cell Motility Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Neutrophil Migration Positive Regulation Of TORC2 Signaling	Nervous System Development Cell Differentiation Clathrin Coat Assembly Neuron Projection Morphogenesis Clathrin-dependent Endocytosis
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	None
GWAS		Hip circumference adjusted for BMI ( 28552196 ) Obesity-related traits ( 23251661 )	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Declining hemoglobin trajectory in blood donors ( 33491795 ) Glaucoma ( 31959993 30054594 ) Glaucoma (high intraocular pressure) ( 33627673 ) Glaucoma (multi-trait analysis) ( 31959993 ) Glaucoma (primary open-angle) ( 33627673 29891935 ) Gut microbiota relative abundance (Prevotella) ( 33208821 ) Heel bone mineral density ( 30598549 ) Intraocular pressure ( 29785010 29617998 30054594 29235454 31798171 28073927 31959993 25173106 24002674 22570627 ) Medication use (antiglaucoma preparations and miotics) ( 31015401 ) Proteinuria and chronic kidney disease ( 26420894 )
Interacting Genes		2 interacting genes: GAS7 PRPF40A	28 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CDC37 CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 LSM4 MCRS1 MECOM MIR196B MYBPC2 NCKAP1 NCKAP1L NTAQ1 PACSIN1 PKNOX1 RPLP0 SF1 SF3A1 SFPQ WASF2 YIF1A
Entrez ID		3071	8522
HPRD ID		00781	16011
Ensembl ID		ENSG00000123338	ENSG00000007237
Uniprot IDs		P55160	O60861
PDB IDs		Not available	2LX7 2YSH
GO Terms Enriched among Interactors		Clathrin Coat Assembly U2-type Prespliceosome U1 SnRNP MRNA Cis Splicing, Via Spliceosome	SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Lamellipodium Lamellipodium Organization Positive Regulation Of Actin Nucleation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cytosol Cortical Actin Cytoskeleton Organization Actin Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Lamellipodium Assembly Regulation Of Lamellipodium Assembly MRNA 3'-splice Site Recognition Actin Filament-based Process Regulation Of Actin Filament Polymerization Lamellipodium Morphogenesis Cortical Cytoskeleton Organization Regulation Of Actin Filament Organization Small GTPase Binding Regulation Of Actin Polymerization Or Depolymerization Cell Projection Morphogenesis Regulation Of Actin Filament Length Regulation Of Lamellipodium Organization Cell Projection Dendrite Extension Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Myeloid Cell Development Regulation Of Cytoskeleton Organization Hemopoiesis RNA 7-methylguanosine Cap Binding Regulation Of Actin Cytoskeleton Organization Extracellular Exosome Positive Regulation Of Cytoskeleton Organization Cell Morphogenesis Cell Projection Assembly MRNA Splicing, Via Spliceosome MRNA Cis Splicing, Via Spliceosome Actin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization RNA Splicing, Via Transesterification Reactions Regulation Of Organelle Organization Poly(U) RNA Binding