IFITM1 and CD81

Number of citations of the paper that reports this interaction (PubMedID 2398277)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		IFITM1	CD81
Description		interferon induced transmembrane protein 1	CD81 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane Protein-containing Complex	Immunological Synapse Cytosol Plasma Membrane Focal Adhesion Basal Plasma Membrane Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain
	Molecular Function	Protein Binding	Virus Receptor Activity Integrin Binding Protein Binding Lipid Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding
	Biological Process	Ossification Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Cell Migration Response To Type II Interferon Response To Interferon-alpha Response To Interferon-beta Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Osteoblast Differentiation Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Type I Interferon-mediated Signaling Pathway	Immunological Synapse Formation Adaptive Immune Response Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Myoblast Fusion Involved In Skeletal Muscle Regeneration Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Regulation Of Cell Motility Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Interferon alpha/beta signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade
Drugs
Diseases
GWAS			Malaria ( 31844061)
Interacting Genes		3 interacting genes: ABHD16A CD81 CR2	62 interacting genes: ADRA1A ADRB2 AQP6 BDKRB2 BST2 CCR2 CCR9 CD19 CD79A CD9 CHRM4 CPLX4 CSNK2B DLG5 EBP ERGIC3 F2RL1 FAM209A FKBP7 GJA4 GLP1R GORAB GPR152 GPR35 GPX8 HNRNPD HRH1 HTR4 IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LBR LHFPL5 LMNA MC4R MCEE MRPS18B MYCBP2 MYOC NEMP1 OXTR PDZK1IP1 PTGFRN RBBP6 RNF128 SAR1A SDHAF4 SHC1 SIRPA SLC18A1 SLC26A6 STX1A THAP4 TMX2 TREX1 TSHR TSPAN4 VKORC1 ZBTB16
Entrez ID		8519	975
HPRD ID		05122	08924
Ensembl ID		ENSG00000185885	ENSG00000110651
Uniprot IDs		P13164	A6NMH8 E9PJK1 H0YEE2 P60033
PDB IDs			1G8Q 1IV5 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2 6U9S 7JIC
Enriched GO Terms of Interacting Partners?		Macrophage Fusion Symbiont Entry Into Host Cell Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Virus Receptor Activity Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Biological Process Involved In Interaction With Host Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Myoblast Fusion Involved In Skeletal Muscle Regeneration Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Mitotic Spindle Astral Microtubule Humoral Immune Response MHC Class II Protein Binding Humoral Immune Response Mediated By Circulating Immunoglobulin Osteoclast Fusion Monoacylglycerol Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Adaptive Immune Response Positive Regulation Of B Cell Receptor Signaling Pathway Complement Receptor Activity Positive Regulation Of T-helper 2 Cell Cytokine Production Tetraspanin-enriched Microdomain Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Transferrin Receptor Binding Monoacylglycerol Lipase Activity Immunological Synapse Formation Immune Effector Process Positive Regulation Of Receptor Clustering Positive Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Complement Activation Complement Receptor Mediated Signaling Pathway Immunoglobulin Receptor Binding Complement Activation, Alternative Pathway Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Receptor Clustering Positive Regulation Of Type 2 Immune Response Phosphatidylserine Metabolic Process Positive Regulation Of T Cell Receptor Signaling Pathway Phosphatidylcholine Lysophospholipase Activity Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	G Protein-coupled Receptor Activity Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size System Process Regulation Of Multicellular Organismal Process Regulation Of Vasoconstriction Regulation Of System Process Negative Regulation Of Dendritic Cell Cytokine Production Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Circulatory System Process Regulation Of Locomotion Regulation Of Dendritic Cell Cytokine Production Myoblast Fusion Involved In Skeletal Muscle Regeneration G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Vascular Process In Circulatory System Cell Surface Receptor Signaling Pathway B Cell Differentiation B Cell Activation Leukocyte Differentiation Chemokine Receptor Activity Developmental Process Regulation Of Production Of Molecular Mediator Of Immune Response Secretion Regulation Of Cytokine Production Involved In Immune Response Cell Activation Cytokine-mediated Signaling Pathway Response To Psychosocial Stress Monocyte Extravasation Positive Regulation Of Vasoconstriction Regulation Of Cell Migration Mononuclear Cell Differentiation Leukocyte Activation Negative Regulation Of Viral Life Cycle Negative Regulation Of Multicellular Organismal Process Lymphocyte Activation Response To Interferon-beta Regulation Of Cell Motility Lymphocyte Differentiation Regulation Of Blood Circulation Regulation Of Blood Pressure Adrenergic Receptor Activity Protein Antigen Binding Ossification Involved In Bone Maturation Positive Regulation Of Cold-induced Thermogenesis
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