PPP1R16A and HLA-E

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PPP1R16A	HLA-E
Description		protein phosphatase 1 regulatory subunit 16A	major histocompatibility complex, class I, E
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class Ib Protein Complex MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Protein Phosphatase Regulator Activity	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding MHC Class I Protein Binding Peptide Antigen Binding T Cell Receptor Binding Natural Killer Cell Lectin-like Receptor Binding Receptor Ligand Activity
	Biological Process		Positive Regulation Of Antibody-dependent Cellular Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Natural Killer Cell Mediated Immunity Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Natural Killer Cell Tolerance Induction Positive Regulation Of Immunoglobulin Production Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response Signal Transduction Antibacterial Humoral Response Antigen Processing And Presentation Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of T Cell Proliferation Protection From Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Defense Response To Gram-positive Bacterium Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways			ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Interferon gamma signaling Interferon alpha/beta signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Blood metabolite levels ( 26401656) Educational attainment ( 25201988) Height ( 28552196) Mean corpuscular hemoglobin concentration ( 27863252 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Hemoglobin levels ( 32327693) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Neuroticism ( 29255261) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		52 interacting genes: ANTKMT ATP23 ATXN7L2 AVPI1 BATF2 C1orf216 C3orf36 CCDC116 CDCA7L CDH24 CKMT1A CKMT1B DDX27 FSD1 HDAC7 HGS HLA-E IDO1 IL16 KAT5 KRTAP19-5 LY6H LZTS2 MCCD1 MRPL12 MYOM1 NDUFAB1 NEK6 NUTF2 PAPSS1 PBDC1 PHPT1 PPP1CA PPP1CB PPP1CC PRKAB2 PRPF31 PUF60 RFLNB RGMA SCNM1 SUV39H1 TFIP11 TLE5 TPP2 TRIP6 TSSK3 TTC23 TXNRD1 UNKL ZFYVE26 ZNF414	9 interacting genes: B2M CALR CD8A F2RL1 KLRC1 KLRC2 KLRD1 PPP1R16A TRAPPC2
Entrez ID		84988	3133
HPRD ID		16454	00877
Ensembl ID		ENSG00000160972	ENSG00000204592
Uniprot IDs		Q96I34	A0A4E9D3W4 A8K8M6 O19682 P13747
PDB IDs			1KPR 1KTL 1MHE 2ESV 3AM8 3BZE 3BZF 3CDG 3CII 5W1V 5W1W 6GGM 6GH1 6GH4 6GHN 6GL1 6ZKW 6ZKX 6ZKY 6ZKZ 7BH8 7NDQ 7NDT 7NDU 7P49 7P4B 8QFY 8RLT 8RLU 8RLV
Enriched GO Terms of Interacting Partners?		PTW/PP1 Phosphatase Complex Phosphocreatine Biosynthetic Process Creatine Kinase Activity Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock	MHC Class I Protein Complex Binding Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity External Side Of Plasma Membrane Protein Antigen Binding Positive Regulation Of Immune System Process Positive Regulation Of Immune Effector Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Positive Regulation Of Immune Response Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Immune Effector Process Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Regulation Of T Cell Mediated Cytotoxicity Carbohydrate Binding Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Lymphocyte Mediated Immunity Receptor Complex Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity MHC Class Ib Receptor Activity Response To Other Organism Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway MHC Class I Peptide Loading Complex Immune Response Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptide Antigen Assembly With MHC Class I Protein Complex T Cell Activation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Innate Immune Response Response To External Biotic Stimulus Mononuclear Cell Differentiation Defense Response To Symbiont Regulation Of T Cell Mediated Immunity Defense Response To Other Organism Immune Response-activating Signaling Pathway Leukocyte Differentiation Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?