PPP1R16A and HLA-E

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PPP1R16A	HLA-E
Gene Name		protein phosphatase 1, regulatory subunit 16A	major histocompatibility complex, class I, E
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Golgi Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Receptor Binding Beta-2-microglobulin Binding MHC Class I Protein Binding Peptide Antigen Binding
	Biological Process		Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Cytokine-mediated Signaling Pathway Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways			DAP12 interactions Interferon Signaling Cytokine Signaling in Immune system Antigen Presentation: Folding, assembly and peptide loading of class I MHC Interferon gamma signaling DAP12 signaling Endosomal/Vacuolar pathway Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ER-Phagosome pathway Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: AES CDH24 DDX27 FAM101B FSD1 HGS HLA-E IDO1 LY6H PAPSS1 PBDC1 PHPT1 PPP1CA PPP1CB PPP1CC PUF60 RGMA TPP2 TRIP6 TXNRD1	7 interactors: B2M CALR CD8A KLRC1 KLRC2 KLRD1 PPP1R16A
Entrez ID		84988	3133
HPRD ID		16454	00877
Ensembl ID		ENSG00000160972	ENSG00000204592
Uniprot IDs		Q96I34	A8K8M6 O19682 P13747 Q6DU44
PDB IDs			1KPR 1KTL 1MHE 2ESV 3AM8 3BZE 3BZF 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Entrainment Of Circadian Clock By Photoperiod Triglyceride Catabolic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Regulation Of Glycogen Catabolic Process Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Dephosphorylation Regulation Of Circadian Rhythm Triglyceride Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Lipid Catabolic Process Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Signaling Cell Division Circadian Rhythm Regulation Of Glycogen Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Dephosphorylation Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Cellular Carbohydrate Metabolic Process Swimming Behavior Kynurenic Acid Biosynthetic Process Peptidyl-histidine Dephosphorylation Regulation Of Signal Transduction Lipid Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Energy Derivation By Oxidation Of Organic Compounds Rhythmic Process Regulation Of Signaling Adherens Junction Organization Negative Regulation Of ATP Citrate Synthase Activity Sulfate Assimilation Cytokine Production Involved In Inflammatory Response Protection From Natural Killer Cell Mediated Cytotoxicity Response To Light Stimulus Response To External Stimulus Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib	Regulation Of Immune System Process Natural Killer Cell Mediated Immunity Regulation Of Immune Response Leukocyte Mediated Immunity Antigen Processing And Presentation Immune System Process Immune Response Signal Transduction Defense Response Signaling Cell Communication Peptide Antigen Assembly With MHC Class I Protein Complex Cytotoxic T Cell Differentiation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Stress Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cellular Response To Stimulus Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Differentiation Innate Immune Response Sequestering Of Calcium Ion Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Antigen Processing And Presentation Of Peptide Antigen Lymphocyte Differentiation Positive Regulation Of Dendritic Cell Chemotaxis Response To Stimulus T Cell Aggregation T Cell Activation Lymphocyte Aggregation Glucocorticoid Receptor Signaling Pathway Leukocyte Aggregation Protein Folding Sequestering Of Metal Ion Leukocyte Cell-cell Adhesion Protein Maturation By Protein Folding Response To Metal Ion Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Surface Receptor Signaling Pathway Lymphocyte Activation Cellular Response To Lithium Ion Protein Refolding Metal Ion Homeostasis Response To Inorganic Substance Leukocyte Activation Regulation Of Defense Response To Virus By Virus Cortical Actin Cytoskeleton Organization Response To Drug Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Calcium-mediated Signaling
Tagcloud ?		acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Difference) ?		acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Intersection) ?