PPFIBP1 and PTPRM

Number of citations of the paper that reports this interaction (PMID 9624153)
49

Data Source:
HPRD (in vitro)

		PPFIBP1	PTPRM
Gene Name		PTPRF interacting protein, binding protein 1 (liprin beta 1)	protein tyrosine phosphatase, receptor type, M
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion	Cytoplasm Integral Component Of Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function		Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Cell Adhesion	Negative Regulation Of Endothelial Cell Proliferation Protein Dephosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Negative Regulation Of Endothelial Cell Migration Retina Layer Formation Negative Regulation Of Angiogenesis Neuron Projection Development Retinal Ganglion Cell Axon Guidance Peptidyl-tyrosine Dephosphorylation Response To Drug Positive Regulation Of Vasodilation
Pathways
Drugs
Diseases
GWAS			Dialysis-related mortality ( 21546767)
Protein-Protein Interactions		7 interactors: PPFIA1 PPFIA2 PPFIA3 PTPRM S100A4 YWHAG YWHAQ	9 interactors: CDH1 CTNNB1 CTNND1 GNB2L1 PCSK5 PPFIBP1 PTPRA PTPRK PTPRS
Entrez ID		8496	5797
HPRD ID		04390	01479
Ensembl ID		ENSG00000110841	ENSG00000173482
Uniprot IDs		Q86W92	E7EVX9 P28827
PDB IDs			1RPM 2C9A 2V5Y
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Acid Secretion Dicarboxylic Acid Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Amino Acid Transport Neurotransmitter Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Carboxylic Acid Transport Organic Acid Transport Establishment Of Localization In Cell Positive Regulation Of Mitochondrion Organization Cellular Localization Organic Anion Transport Secretion By Cell Regulation Of Mitochondrion Organization Synaptic Transmission Secretion Anion Transport Regulation Of Establishment Of Protein Localization Signaling Regulation Of Synaptic Plasticity Cell-matrix Adhesion Cell Communication Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cell-substrate Adhesion Cell-cell Signaling Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Negative Regulation Of Stress Fiber Assembly Regulation Of Synaptic Transmission Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Short-term Neuronal Synaptic Plasticity Cell Adhesion Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Transport Positive Regulation Of Organelle Organization Negative Regulation Of Protein Localization To Plasma Membrane Protein Targeting Retinal Ganglion Cell Axon Guidance Regulation Of Intracellular Transport Regulation Of Signaling Retina Layer Formation	Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Cellular Response To Indole-3-methanol Cell Adhesion Regulation Of Wnt Signaling Pathway Digestive Tract Development Digestive System Development Protein Localization To Cell Surface Regulation Of Protein Localization To Cell Surface Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Embryonic Development Regulation Of Canonical Wnt Signaling Pathway Protein Dephosphorylation Brain Development Adherens Junction Assembly Regulation Of Epithelial Cell Proliferation Head Development Epithelial Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cell Cycle Regulation Of Morphogenesis Of A Branching Structure Cellular Response To Organic Substance Central Nervous System Development Multicellular Organismal Development Execution Phase Of Apoptosis Anatomical Structure Development Renin Secretion Into Blood Stream Negative Regulation Of Signal Transduction Forebrain Development Embryo Development Dephosphorylation Lens Development In Camera-type Eye Cellular Response To Organonitrogen Compound Negative Regulation Of Signaling Nervous System Development Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of CAMP Catabolic Process Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Single Organismal Cell-cell Adhesion Regulation Of Embryonic Development Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Epithelial Cell Proliferation
Tagcloud ?			12q21 18p11 20q12 7q31 aberrations amplified braf chromosomal colorectal connected covering deleted deletions gains glioma hypermethylated losses methylator molecularly oncogenes phosphatases ptprq ptprt ptprz1 ptps sporadic suppressors unbalanced z1
Tagcloud (Difference) ?			12q21 18p11 20q12 7q31 aberrations amplified braf chromosomal colorectal connected covering deleted deletions gains glioma hypermethylated losses methylator molecularly oncogenes phosphatases ptprq ptprt ptprz1 ptps sporadic suppressors unbalanced z1
Tagcloud (Intersection) ?