PPFIBP1 and PPFIA2

Number of citations of the paper that reports this interaction (PMID 9624153)
49

Data Source:
HPRD (in vivo, in vitro)

		PPFIBP1	PPFIA2
Gene Name		PTPRF interacting protein, binding protein 1 (liprin beta 1)	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion	Cytoplasm Cytosol Cell Surface Presynaptic Active Zone Extracellular Vesicular Exosome
	Molecular Function		Protein Binding Protein Complex Binding
	Biological Process	Cell Adhesion	Cell-matrix Adhesion Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Schizophrenia ( 22885689)
Protein-Protein Interactions		7 interactors: PPFIA1 PPFIA2 PPFIA3 PTPRM S100A4 YWHAG YWHAQ	13 interactors: CAST CDC5L ERC2 GIT1 ITSN1 PPFIA1 PPFIA3 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRG PTPRS
Entrez ID		8496	8499
HPRD ID		04390	04392
Ensembl ID		ENSG00000110841	ENSG00000139220
Uniprot IDs		Q86W92	G3V200 O75334
PDB IDs			3TAC 3TAD
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Acid Secretion Dicarboxylic Acid Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Amino Acid Transport Neurotransmitter Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Carboxylic Acid Transport Organic Acid Transport Establishment Of Localization In Cell Positive Regulation Of Mitochondrion Organization Cellular Localization Organic Anion Transport Secretion By Cell Regulation Of Mitochondrion Organization Synaptic Transmission Secretion Anion Transport Regulation Of Establishment Of Protein Localization Signaling Regulation Of Synaptic Plasticity Cell-matrix Adhesion Cell Communication Regulation Of Protein Localization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cell-substrate Adhesion Cell-cell Signaling Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Negative Regulation Of Stress Fiber Assembly Regulation Of Synaptic Transmission Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Short-term Neuronal Synaptic Plasticity Cell Adhesion Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Transport Positive Regulation Of Organelle Organization Negative Regulation Of Protein Localization To Plasma Membrane Protein Targeting Retinal Ganglion Cell Axon Guidance Regulation Of Intracellular Transport Regulation Of Signaling Retina Layer Formation	Peptidyl-tyrosine Dephosphorylation Enzyme Linked Receptor Protein Signaling Pathway Protein Dephosphorylation Signaling Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Communication Dephosphorylation Signal Transduction Glutamate Secretion Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Acid Secretion Dicarboxylic Acid Transport Ephrin Receptor Signaling Pathway Neurotransmitter Secretion Cell Surface Receptor Signaling Pathway Response To Stimulus Regulation Of Neurotransmitter Levels Synaptic Transmission Nervous System Development Amino Acid Transport Neurotransmitter Transport Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Receptor Binding Presynaptic Membrane Assembly Generation Of Neurons Negative Regulation Of Stress Fiber Assembly Presynaptic Membrane Organization Neurogenesis Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Cellular Process Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling
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