PARP10 and HIST2H2BE

Number of citations of the paper that reports this interaction (PMID 15674325)
20

Data Source:
BioGRID (enzymatic study)

		PARP10	HIST2H2BE
Gene Name		poly (ADP-ribose) polymerase family, member 10	histone cluster 2, H2be
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus	Nucleosome Extracellular Space Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding K63-linked Polyubiquitin Binding	DNA Binding Protein Heterodimerization Activity
	Biological Process	Protein ADP-ribosylation Negative Regulation Of Gene Expression Regulation Of Chromatin Assembly Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Viral Genome Replication Negative Regulation Of Fibroblast Proliferation Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Negative Regulation Of Protein K63-linked Ubiquitination	Innate Immune Response In Mucosa Chromatin Organization Nucleosome Assembly Antibacterial Humoral Response Defense Response To Gram-positive Bacterium
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: H3F3A HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE IKBKG MYC PCNA UBC	74 interactors: AIRE AKT1 ANP32A ARID1B ATF2 ATXN7L3 BAZ1B BRD2 BRD7 CDK9 CHFR CREBBP DNMT3L DYRK2 EP300 GADD45A GATAD2A GATAD2B GZMA HDAC2 HIPK2 HIRA HIRIP3 HIST1H4A HIST2H2AC HSPD1 IL33 IL7R KAT2A KAT2B KPNA1 LALBA LOX MAP4K4 MDM2 MSL1 MSL2 MST1 NAP1L4 NCL NPM1 PARP10 PBRM1 PELP1 PRMT6 PTMA RAG1 RCC1 RNF20 RNF40 RNF8 RPS6KA5 SAP30 SART3 SIRT7 SMARCA4 SSRP1 STK4 TAF1A TAF1B TBL1X TBL1XR1 TCF20 TGM2 TNPO1 TSPY1 UBC UBE2A USP12 USP15 USP22 USP46 USP49 VRK1
Entrez ID		84875	8349
HPRD ID		15100	03494
Ensembl ID		ENSG00000178685	ENSG00000184678
Uniprot IDs		E9PNI7 Q53GL7	Q16778
PDB IDs		2DHX 3HKV
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Silencing Protein-DNA Complex Assembly DNA Packaging Chromosome Organization DNA Methylation DNA Conformation Change Negative Regulation Of Gene Expression, Epigenetic Chromatin Organization DNA Modification DNA Replication-dependent Nucleosome Assembly Gene Silencing DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Cellular Macromolecular Complex Assembly Negative Regulation Of Biosynthetic Process MAPK Cascade DNA Replication-independent Nucleosome Assembly Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Signal Transduction By Phosphorylation Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of RNA Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Nucleobase-containing Compound Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Organelle Organization MyD88-dependent Toll-like Receptor Signaling Pathway Heterocycle Metabolic Process	Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Organelle Organization Cellular Protein Modification Process Cellular Metabolic Process Regulation Of Gene Expression Gene Expression Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Chromatin Remodeling Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Assembly Or Disassembly Protein Catabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Histone Acetylation Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Internal Peptidyl-lysine Acetylation Cellular Protein Catabolic Process Viral Process Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation
Tagcloud ?			5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis
Tagcloud (Difference) ?			5p15 angiogenesis aza bdkrb2 biomarker dc encoding fgf7 gastric global heterozygosity hypermethylation immunoprecipitation invasion irx1 located locus lost microarray n87 nci partially restored restoring serve sgc susceptibility transfection tumorigenesis
Tagcloud (Intersection) ?