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PARP10 and MYC
Number of citations of the paper that reports this interaction (PMID
15674325
)
20
Data Source:
BioGRID
(imaging technique)
HPRD
(in vivo, in vitro)
PARP10
MYC
Gene Name
poly (ADP-ribose) polymerase family, member 10
v-myc avian myelocytomatosis viral oncogene homolog
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Apparatus
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Protein Complex
Molecular Function
NAD+ ADP-ribosyltransferase Activity
Protein Binding
K63-linked Polyubiquitin Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Complex Binding
Protein Dimerization Activity
Repressing Transcription Factor Binding
E-box Binding
Biological Process
Protein ADP-ribosylation
Negative Regulation Of Gene Expression
Regulation Of Chromatin Assembly
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Protein Import Into Nucleus, Translocation
Negative Regulation Of Viral Genome Replication
Negative Regulation Of Fibroblast Proliferation
Protein Poly-ADP-ribosylation
Protein Auto-ADP-ribosylation
Negative Regulation Of Protein K63-linked Ubiquitination
Negative Regulation Of Transcription From RNA Polymerase II Promoter
MAPK Cascade
Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Mesenchymal Cell Proliferation
Energy Reserve Metabolic Process
Chromatin Remodeling
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Cellular Iron Ion Homeostasis
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Positive Regulation Of Cell Proliferation
Response To Gamma Radiation
Gene Expression
Regulation Of Gene Expression
Oxygen Transport
Regulation Of Telomere Maintenance
Negative Regulation Of Stress-activated MAPK Cascade
Cellular Response To UV
Cellular Response To Drug
Response To Drug
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Fibroblast Apoptotic Process
Negative Regulation Of Monocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Chromosome Organization
Negative Regulation Of Cell Division
Canonical Wnt Signaling Pathway
Response To Growth Factor
Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Response To DNA Damage Stimulus
Pathways
Loss of Function of TGFBR2 in Cancer
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Signaling by Wnt
Cyclin E associated events during G1/S transition
binding of TCF/LEF:CTNNB1 to target gene promoters
TGFBR1 LBD Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Generic Transcription Pathway
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
Signaling by NOTCH1
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Mitotic G1-G1/S phases
FBXW7 Mutants and NOTCH1 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Loss of Function of SMAD2/3 in Cancer
Signaling by NOTCH
formation of the beta-catenin:TCF transactivating complex
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
S Phase
Cell Cycle, Mitotic
Loss of Function of TGFBR1 in Cancer
NOTCH1 Intracellular Domain Regulates Transcription
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
TCF dependent signaling in response to WNT
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Cyclin A:Cdk2-associated events at S phase entry
Signaling by WNT in cancer
Constitutive Signaling by NOTCH1 PEST Domain Mutants
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Bladder cancer (
20972438
)
Breast cancer (
23535729
)
Colorectal cancer (
23266556
)
Multiple sclerosis (
21833088
)
Ovarian cancer (
23535730
20852632
)
Urinary bladder cancer (
20348956
18794855
)
Protein-Protein Interactions
9 interactors:
H3F3A
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H2BE
IKBKG
MYC
PCNA
UBC
126 interactors:
ACTL6A
ATAD2
AXIN1
BCL2
BIN1
BRCA1
BRD3
BTRC
CCNH
CCNT1
CDC6
CDCA7L
CDK1
CDK4
CDK6
CDK8
CDKN2A
CEBPA
CEBPB
CEP57
CREB1
CREBBP
CSNK2A1
CSNK2A2
DNMT3A
EFNB1
ELF3
EP300
EP400
FBXO8
FBXW7
FBXW8
GCN1L1
GPX2
GSK3A
GSK3B
GTF2B
GTF2F1
GTF2I
HNRNPD
HSP90AA1
HUWE1
ING4
KAT2A
KAT2B
KAT5
KDM1A
KIAA1524
KIDINS220
KPNA2
LDOC1
MAP2K1
MAPK1
MAPK3
MAPK7
MAPK8
MAX
MED1
MED12
MED14
MED16
MEN1
MINA
MLH1
MOK
MXD1
MXI1
MYCBP
MYCBP2
NEK11
NFYB
NFYC
NMI
NOTCH3
NUCB1
PAK2
PARP10
PFDN5
PLAU
PML
POLR2A
PRDX1
PSMC3
RAF1
RB1
RBL1
RELA
RUVBL1
SAP130
SF3B1
SKP1
SKP2
SMAD2
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SNIP1
SNRNP70
SP1
SPAG9
SUPT3H
TADA2A
TAF1B
TAF5
TAF9
TBP
TFAP2A
TFAP2B
TIAM1
TONSL
TP73
TRIM6
TRRAP
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
UBB
USP37
YEATS4
YY1
ZBTB17
ZNF281
Entrez ID
84875
4609
HPRD ID
15100
01818
Ensembl ID
ENSG00000178685
ENSG00000136997
Uniprot IDs
E9PNI7
Q53GL7
P01106
PDB IDs
2DHX
3HKV
1A93
1EE4
1MV0
1NKP
2A93
2OR9
Enriched GO Terms of Interacting Partners
?
DNA Methylation On Cytosine
Chromatin Silencing At RDNA
Nucleosome Assembly
Chromatin Assembly
Nucleosome Organization
Chromatin Assembly Or Disassembly
Chromatin Silencing
Protein-DNA Complex Assembly
DNA Packaging
Chromosome Organization
DNA Methylation
DNA Conformation Change
Negative Regulation Of Gene Expression, Epigenetic
Chromatin Organization
DNA Modification
DNA Replication-dependent Nucleosome Assembly
Gene Silencing
DNA Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Response To Stress
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Negative Regulation Of Gene Expression
Regulation Of Gene Expression, Epigenetic
Cellular Macromolecular Complex Assembly
Negative Regulation Of Biosynthetic Process
MAPK Cascade
DNA Replication-independent Nucleosome Assembly
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Signal Transduction By Phosphorylation
Regulation Of Transcription, DNA-templated
Cellular Response To DNA Damage Stimulus
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Regulation Of RNA Metabolic Process
I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Nucleobase-containing Compound Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Organelle Organization
MyD88-dependent Toll-like Receptor Signaling Pathway
Heterocycle Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
Positive Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Gene Expression
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Aromatic Compound Metabolic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
DNA-templated Transcription, Initiation
Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Viral Process
Regulation Of Cellular Process
Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Cell Cycle
Negative Regulation Of Biosynthetic Process
Cell Cycle Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Chromatin Modification
Negative Regulation Of Gene Expression
Cellular Response To Stress
Mitotic Cell Cycle
Histone Acetylation
Negative Regulation Of Transcription, DNA-templated
Chromatin Organization
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Regulation Of Cell Cycle
Internal Protein Amino Acid Acetylation
Tagcloud
?
augment
augments
bait
cbp
coactivator
coil
coiled
enhances
except
hybrid
ifngamma
instead
interactor
interacts
interestingly
intrinsic
lacks
nmi
potentiate
recruitment
reveal
screen
stat
stat1
stat2
stat5
stat5b
stats
yeast
Tagcloud (Difference)
?
augment
augments
bait
cbp
coactivator
coil
coiled
enhances
except
hybrid
ifngamma
instead
interactor
interacts
interestingly
intrinsic
lacks
nmi
potentiate
recruitment
reveal
screen
stat
stat1
stat2
stat5
stat5b
stats
yeast
Tagcloud (Intersection)
?