PARP10 and H3F3A

Number of citations of the paper that reports this interaction (PMID 15674325)
20

Data Source:
HPRD (in vitro)

		PARP10	H3F3A
Gene Name		poly (ADP-ribose) polymerase family, member 10	H3 histone, family 3A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus	Nuclear Chromosome Nuclear Nucleosome Extracellular Region Nucleus Nucleoplasm Protein Complex Extracellular Vesicular Exosome
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding K63-linked Polyubiquitin Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Protein ADP-ribosylation Negative Regulation Of Gene Expression Regulation Of Chromatin Assembly Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Protein Import Into Nucleus, Translocation Negative Regulation Of Viral Genome Replication Negative Regulation Of Fibroblast Proliferation Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Negative Regulation Of Protein K63-linked Ubiquitination	Chromatin Silencing At RDNA DNA Replication-independent Nucleosome Assembly Blood Coagulation Gene Expression Positive Regulation Of Cell Growth DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Cellular Senescence Signaling by Wnt M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: H3F3A HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE IKBKG MYC PCNA UBC	25 interactors: ASF1A ASF1B BPTF BRD1 CABIN1 CARM1 CBX3 CHD1 CREBBP DAXX KAT2B KMT2A MAPK9 NOS3 PARP10 SETD7 SMARCA1 SMARCA4 SMARCA5 SS18 SSRP1 SUPT16H TLE2 UHRF1 ZMYND11
Entrez ID		84875	3020
HPRD ID		15100	03082
Ensembl ID		ENSG00000178685	ENSG00000163041
Uniprot IDs		E9PNI7 Q53GL7	B2R4P9 P84243
PDB IDs		2DHX 3HKV	2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Silencing Protein-DNA Complex Assembly DNA Packaging Chromosome Organization DNA Methylation DNA Conformation Change Negative Regulation Of Gene Expression, Epigenetic Chromatin Organization DNA Modification DNA Replication-dependent Nucleosome Assembly Gene Silencing DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Cellular Macromolecular Complex Assembly Negative Regulation Of Biosynthetic Process MAPK Cascade DNA Replication-independent Nucleosome Assembly Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Signal Transduction By Phosphorylation Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of RNA Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Nucleobase-containing Compound Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Organelle Organization MyD88-dependent Toll-like Receptor Signaling Pathway Heterocycle Metabolic Process	Chromatin Organization Chromatin Modification Chromosome Organization Organelle Organization Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Chromatin Remodeling Gene Expression Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process DNA Replication-independent Nucleosome Assembly Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Nucleosome Assembly Internal Protein Amino Acid Acetylation Peptidyl-lysine Modification Protein Acetylation Chromatin Assembly Negative Regulation Of Cellular Metabolic Process DNA Conformation Change Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Viral Process
Tagcloud ?			36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights hist1h3b idh1 innovative k27m mark marks notably opportunity pediatric polycomb tailored trimethylation underlies
Tagcloud (Difference) ?			36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights hist1h3b idh1 innovative k27m mark marks notably opportunity pediatric polycomb tailored trimethylation underlies
Tagcloud (Intersection) ?