PARP10

Name	poly(ADP-ribose) polymerase family member 10
Structure
Interactors	14 interactors: AURKA DTX2 H2AC20 H2BC21 H3-3A H3C1 H4C1 MYC PARP14 PCNA PLK1 RAN RNF26 UBC
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Transcription Corepressor Activity NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding DNA-binding Transcription Factor Binding NAD+-protein-lysine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	DNA Repair Chromatin Organization DNA Damage Response Negative Regulation Of Gene Expression Viral Protein Processing Translesion Synthesis Negative Regulation Of NF-kappaB Transcription Factor Activity NAD+ Biosynthetic Process Via The Salvage Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Fibroblast Proliferation Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways	Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
GWAS	Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Brain morphology (MOSTest) ( 32665545 ) Hip index ( 34021172 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Menarche (age at onset) ( 25231870 ) Red cell distribution width ( 32888494 )
Entrez ID	84875
HPRD ID	15100
Ensembl ID	ENSG00000178685
Uniprot IDs	B4E0C4 E9PK67 E9PNI7 E9PPE7 Q53GL7
PDB IDs	2DHX 3HKV 5LX6 6FXI
GO Terms Enriched among Interactors ?	Chromosome Organization Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome Chromatin Organization Chromatin Remodeling Chromosome Nucleosome Assembly Telomere Organization Nucleosome Organization Protein-DNA Complex Assembly Nucleoplasm Nucleus Organelle Organization Centrosome Separation Epigenetic Regulation Of Gene Expression Mitotic Spindle Organization Extracellular Exosome Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Cell Cycle Protein Localization To Centrosome Spindle Midzone Mitotic Cell Cycle Phase Transition Protein-containing Complex Liver Regeneration Cell Cycle Phase Transition Spindle Organization Centriole Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Regulation Of Cell Division Post-translational Protein Modification Mitotic Sister Chromatid Segregation Midbody Mitotic Spindle Pole Sister Chromatid Segregation Spindle Microtubule Peptidyl-serine Phosphorylation DNA Binding Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding PCNA Complex Replisome Male Germ Cell Nucleus Protein Localization To Cytoskeleton Centrosome Cycle Protein Localization To Chromatin G2/M Transition Of Mitotic Cell Cycle