CDC42BPA and LIMK1

Number of citations of the paper that reports this interaction (PMID 10559936)
214

Data Source:
HPRD (in vivo, in vitro)

		CDC42BPA	LIMK1
Gene Name		CDC42 binding protein kinase alpha (DMPK-like)	LIM domain kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cell-cell Junction Cell Leading Edge Actomyosin Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol Focal Adhesion Neuron Projection
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding Identical Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Heat Shock Protein Binding Protein Heterodimerization Activity
	Biological Process	Microtubule Cytoskeleton Organization Protein Phosphorylation Nuclear Migration Cell Migration Actomyosin Structure Organization Actin Cytoskeleton Reorganization Intracellular Signal Transduction Regulation Of Catalytic Activity	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Positive Regulation Of Axon Extension Ephrin Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly
Pathways			EPHB-mediated forward signaling Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema3A PAK dependent Axon repulsion Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CDC42 LIMK1 LIMK2 MYL2 MYL9 PPP1R12C	25 interactors: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 HIST1H1A LATS1 LIMK2 MAPK14 MAPKAPK2 MBP NRG1 PAK1 PAK2 PAK4 PXN RLIM ROCK1 SRPK1 SSH3 YWHAZ
Entrez ID		8476	3984
HPRD ID		04562	03210
Ensembl ID		ENSG00000143776	ENSG00000106683
Uniprot IDs		F5H5N0 Q5VT25	P53667
PDB IDs			3S95
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Axon Guidance Heart Contraction Movement Of Cell Or Subcellular Component Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Cell Development Neuron Projection Morphogenesis Actin Filament-based Process Muscle Cell Fate Specification Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Positive Regulation Of Hair Follicle Cell Proliferation Regulation Of Muscle Contraction Cell Projection Morphogenesis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Part Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Actin Filament Branching Submandibular Salivary Gland Formation Neuron Development Cardiac Muscle Tissue Development Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Muscle Contraction Cell Morphogenesis Neuron Differentiation Cytoskeleton Organization Cell Projection Organization Establishment Of Golgi Localization Phagocytosis Muscle System Process Fc Receptor Signaling Pathway Positive Regulation Of Metalloenzyme Activity Positive Regulation Of Cell Projection Organization Locomotion Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Fate Commitment Blood Circulation Positive Regulation Of Cellular Component Biogenesis Striated Muscle Tissue Development Neuron Fate Determination	Phosphorylation Cellular Protein Modification Process Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Signal Transduction By Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Protein Metabolic Process Platelet Activation Signaling Regulation Of Kinase Activity Cell Communication Response To External Stimulus Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Cellular Amino Acid Metabolic Process Signal Transduction Cell Differentiation Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Organelle Organization Locomotion Immune Response Neurogenesis Apoptotic Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Regulation Of Signaling Defense Response Programmed Cell Death Organelle Organization Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?			alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845
Tagcloud (Difference) ?			alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845
Tagcloud (Intersection) ?