CDC42BPA and LIMK2

Number of citations: 0 (PubMedID 11340065)
Data Source: HPRD (in vitro)

		CDC42BPA	LIMK2
Name		CDC42 binding protein kinase alpha	LIM domain kinase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Lamellipodium Cell Leading Edge Actomyosin Cell Projection Extracellular Exosome	Nucleus Cytoplasm Cis-Golgi Network Centrosome Spindle Cytoskeleton Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Cell Migration Actin Cytoskeleton Organization Actomyosin Structure Organization	Protein Phosphorylation Spermatogenesis Actin Cytoskeleton Organization Astral Microtubule Organization Establishment Of Vesicle Localization Head Development Cornea Development In Camera-type Eye Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle	EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs
Drugs		None	Fostamatinib
GWAS		Blond vs. brown/black hair color ( 30531825 ) Blood urea nitrogen levels ( 31152163 ) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697 ) Diastolic blood pressure ( 28135244 ) Low density lipoprotein cholesterol levels ( 33339817 ) Macular thickness ( 30535121 ) Mercury levels ( 26025379 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 ) Optic cup area ( 25631615 31798171 ) Optic disc area ( 25631615 31798171 28073927 ) Optic disc size ( 31809533 ) SAPHO syndrome ( 33816493 ) Smoking initiation ( 33082346 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist circumference adjusted for body mass index ( 34021172 ) White blood cell count ( 32888494 )	Eosinophil count ( 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 ) Fish- and plant-related diet ( 32066663 ) Mean reticulocyte volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil percentage of granulocytes ( 27863252 ) Oily fish consumption ( 32066663 ) Paclitaxel-induced neuropathy ( 23776197 ) Pork consumption ( 32066663 ) Red cell distribution width ( 32888494 ) Sum eosinophil basophil counts ( 27863252 ) Type 2 diabetes nephropathy ( 21150874 )
Novel Interactors		None recorded	1 novel interactors: FCGR2A
Interacting Genes		10 interacting genes: CDC42 LIMK1 LIMK2 MYL2 MYL9 PPM1A PPP1R12C SNAPIN TAF1 USP7	12 interacting genes: CDC42BPA CFL1 FBXO7 GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1
Entrez ID		8476	3985
HPRD ID		04562	03585
Ensembl ID		ENSG00000143776	ENSG00000182541
Uniprot IDs		A0A0A0MRJ0 A0A0A0MRJ1 Q5VT25	P53671
PDB IDs		Not available	1X6A 4TPT 5NXD 7QHG 8GI4 8S3X 8WSW
GO Terms Enriched among Interactors		Actin Filament-based Process Actin Cytoskeleton Organization Supramolecular Fiber Organization Myosin Heavy Chain Binding Actomyosin Structure Organization Heart Contraction Cytoskeleton Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Organelle Organization Cytoskeleton Organization Myofibril Assembly Heart Process Structural Constituent Of Muscle Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Stress Fiber Assembly Actin Filament Organization Establishment Of Organelle Localization Regulation Of Cell Projection Organization Myosin Complex Myofibril Regulation Of Intracellular Transport Positive Regulation Of Actin Filament Bundle Assembly Actin Filament Bundle Assembly Muscle Cell Fate Specification Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Late Endosome To Lysosome Transport Actin Filament Bundle Organization P53 Binding Cellular Component Assembly Protein Serine Kinase Activity Protein Phosphorylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Component Organization GBD Domain Binding Storage Vacuole Organelle Transport Along Microtubule Negative Regulation Of Protein Autoubiquitination Stress Fiber Phosphorylation Protein Modification Process Regulation Of Cell Growth Regulation Of Stress Fiber Assembly Protein Serine/threonine Kinase Activity Developmental Process Endothelin Receptor Signaling Pathway Involved In Heart Process Establishment Of Vesicle Localization Symbiont-mediated Disruption Of Host Cell PML Body Organelle Localization	Lamellipodium Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Establishment Of Cell Polarity Regulation Of Establishment Or Maintenance Of Cell Polarity Cytoskeleton Organization Protein Serine Kinase Activity Protein Phosphorylation Internode Region Of Axon Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Protein Kinase Activity Actin Filament Depolymerization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Actin Filament Severing Regulation Of Multicellular Organismal Process Myelination Axon Ensheathment Kinase Activity Actomyosin Structure Organization Positive Regulation Of Multicellular Organismal Process Myelination In Peripheral Nervous System Positive Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Cytosol Organelle Organization Regulation Of Proteolysis Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Immune System Process Muscle Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Focal Adhesion Assembly Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cytoskeleton Organization Regulation Of Multicellular Organismal Development Protein Depolymerization Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death