GTPBP3 and DCAF8

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
HPRD (two hybrid)

		GTPBP3	DCAF8
Description		GTP binding protein 3, mitochondrial	DDB1 and CUL4 associated factor 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Transferase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity TRNA 5-taurinomethyluridine Synthase Activity	Protein Binding
	Biological Process	TRNA Wobble Uridine Modification TRNA Modification TRNA Processing TRNA Methylation Mitochondrial TRNA Wobble Uridine Modification	Myotube Cell Development Protein Ubiquitination
Pathways		tRNA modification in the mitochondrion	Neddylation
Drugs
Diseases
GWAS		Mitochondrial DNA copy number ( 30704525)	Breast size ( 27182965) Lung function (FEV1/FVC) ( 30061609) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		29 interacting genes: BEND7 CAPN3 CCDC32 CIC COPS5 DCAF8 DPPA4 GNE INCA1 ITGB3BP MBD3L1 MEOX2 MESD OGT PARP11 PFKL POLDIP3 PPP1R18 PRPF3 PTAFR RALY RIBC2 SERTAD3 SINHCAF TBC1D3B TBC1D3G ZFP90 ZNF69 ZNF774	17 interacting genes: CRYAA DDB1 GSK3A GTPBP3 MDFI PIK3R3 PRMT1 PRMT8 RAF1 RBM11 RBPMS SPAST SUV39H1 THAP1 TNS2 TRIM54 WDR76
Entrez ID		84705	50717
HPRD ID		12255	18300
Ensembl ID		ENSG00000130299	ENSG00000132716
Uniprot IDs		B7Z563 Q969Y2	B7Z8C9 Q5TAQ9
PDB IDs			3I8E
Enriched GO Terms of Interacting Partners?			Epigenetic Programming Of Gene Expression Protein-arginine Omega-N Monomethyltransferase Activity Histone Methyltransferase Activity Peptidyl-arginine Methylation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H4 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Methylation Insulin Receptor Signaling Pathway Epigenetic Programming In The Zygotic Pronuclei Identical Protein Binding Nucleus S-adenosyl-L-methionine Binding Macromolecule Methylation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Viral Protein Processing S-adenosylmethionine-dependent Methyltransferase Activity Viral Process Developmental Process Regulation Of Microtubule Cytoskeleton Organization Enzyme Binding Protein Methylation Methyltransferase Activity Regulation Of Microtubule Depolymerization Cellular Developmental Process Protein-containing Complex Assembly Negative Regulation Of UDP-glucose Catabolic Process Cell Differentiation Protein Homooligomerization GATOR1 Complex Binding Chromatin Organization Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus RNA Processing Regulation Of Macromolecule Metabolic Process Heterochromatin Response To Stress Protein-containing Complex Organization Negative Regulation Of Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Complex Oligomerization Death-inducing Signaling Complex Assembly TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Regulation Of Microtubule-based Process Regulation Of Alternative MRNA Splicing, Via Spliceosome
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