DCAF8 and WDR76

Number of citations of the paper that reports this interaction (PubMedID 33288900)
75

Data Source:
BioGRID (pull down)

		DCAF8	WDR76
Description		DDB1 and CUL4 associated factor 8	WD repeat domain 76
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul4-RING E3 Ubiquitin Ligase Complex	Heterochromatin Nucleus Site Of DNA Damage
	Molecular Function	Protein Binding	DNA Binding Protein Binding Enzyme Binding
	Biological Process	Myotube Cell Development Protein Ubiquitination	DNA Damage Response Regulation Of DNA Damage Checkpoint
Pathways		Neddylation
Drugs
Diseases
GWAS		Breast size ( 27182965) Lung function (FEV1/FVC) ( 30061609) Squamous cell lung carcinoma ( 28604730)	Lung cancer ( 28604730) Serum albumin levels ( 23022100)
Interacting Genes		17 interacting genes: CRYAA DDB1 GSK3A GTPBP3 MDFI PIK3R3 PRMT1 PRMT8 RAF1 RBM11 RBPMS SPAST SUV39H1 THAP1 TNS2 TRIM54 WDR76	3 interacting genes: DCAF8 KRAS NRAS
Entrez ID		50717	79968
HPRD ID		18300	07804
Ensembl ID		ENSG00000132716	ENSG00000092470
Uniprot IDs		B7Z8C9 Q5TAQ9	A0A0C4DFX7 Q9H967
PDB IDs		3I8E
Enriched GO Terms of Interacting Partners?		Epigenetic Programming Of Gene Expression Protein-arginine Omega-N Monomethyltransferase Activity Histone Methyltransferase Activity Peptidyl-arginine Methylation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H4 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Methylation Insulin Receptor Signaling Pathway Epigenetic Programming In The Zygotic Pronuclei Identical Protein Binding Nucleus S-adenosyl-L-methionine Binding Macromolecule Methylation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Viral Protein Processing S-adenosylmethionine-dependent Methyltransferase Activity Viral Process Developmental Process Regulation Of Microtubule Cytoskeleton Organization Enzyme Binding Protein Methylation Methyltransferase Activity Regulation Of Microtubule Depolymerization Cellular Developmental Process Protein-containing Complex Assembly Negative Regulation Of UDP-glucose Catabolic Process Cell Differentiation Protein Homooligomerization GATOR1 Complex Binding Chromatin Organization Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus RNA Processing Regulation Of Macromolecule Metabolic Process Heterochromatin Response To Stress Protein-containing Complex Organization Negative Regulation Of Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Complex Oligomerization Death-inducing Signaling Complex Assembly TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Regulation Of Microtubule-based Process Regulation Of Alternative MRNA Splicing, Via Spliceosome	GDP Binding G Protein Activity Ras Protein Signal Transduction Response To Isolation Stress Small GTPase-mediated Signal Transduction GMP Binding Forebrain Astrocyte Development MAPK Cascade LRR Domain Binding GTPase Activity Response To Gravity Protein-containing Complex Binding GTP Binding Type I Pneumocyte Differentiation Myoblast Proliferation Cardiac Muscle Cell Proliferation Lung Epithelial Cell Differentiation Positive Regulation Of Cellular Senescence Rac Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Glial Cell Proliferation Astrocyte Development Glial Cell Proliferation Golgi Membrane Lung Cell Differentiation Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Long-term Neuronal Synaptic Plasticity Cul4-RING E3 Ubiquitin Ligase Complex Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Protein-membrane Adaptor Activity Myotube Cell Development Response To Mineralocorticoid Homeostasis Of Number Of Cells Within A Tissue Regulation Of Glial Cell Proliferation Intracellular Signaling Cassette Cell Development Muscle Cell Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cellular Senescence Negative Regulation Of Epithelial Cell Differentiation Visual Learning Visual Behavior Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Gliogenesis Endoplasmic Reticulum Membrane Skeletal Muscle Cell Differentiation Glial Cell Development Tertiary Granule Membrane Striated Muscle Cell Differentiation
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