DCAF8 and DDB1

Number of citations of the paper that reports this interaction (PMID 16949367)
175

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		DCAF8	DDB1
Gene Name		DDB1 and CUL4 associated factor 8	damage-specific DNA binding protein 1, 127kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Vesicular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	DNA Binding Damaged DNA Binding Protein Binding
	Biological Process	Protein Ubiquitination	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Viral Process Wnt Signaling Pathway Histone H2A Monoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Interaction With Symbiont UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Viral Release From Host Cell
Pathways			Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER Dual incision reaction in GG-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: DDB1 GTPBP3 MDFI PRMT1 PRMT8 RAF1 RBPMS SUV39H1 THAP1	40 interactors: ABL1 BRAP CDT1 CNOT2 COPS2 COPS5 COPS8 CUL4A CUL4B DCAF11 DCAF8 DCLRE1C DDB2 DET1 DTL DYRK2 ERCC8 GPS1 HIST1H1C HIST1H3A HOXD3 IP6K1 LMO4 MAFB MEF2A PIN1 RASSF1 RBX1 SALL2 SIN3A SKP2 STAT1 SUPT3H TP53 UNG USP40 VAMP3 WDTC1 XPA ZNF277
Entrez ID		50717	1642
HPRD ID		18300	10952
Ensembl ID		ENSG00000132716	ENSG00000167986
Uniprot IDs		B7Z8C9 Q5TAQ9	Q16531
PDB IDs		3I8E	2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4E54 4E5Z
Enriched GO Terms of Interacting Partners?		Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Modification Peptidyl-arginine N-methylation Histone Methylation Histone H4-R3 Methylation Histone Arginine Methylation Peptidyl-arginine Methylation Protein Methylation Chromatin Modification Chromatin Organization Chromosome Organization Death-inducing Signaling Complex Assembly Methylation Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of Transcription, DNA-templated Regulation Of Protein Import Into Nucleus Negative Regulation Of Megakaryocyte Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Phosphorylation Regulation Of RNA Metabolic Process Regulation Of Protein Localization To Nucleus Histone H3-K9 Dimethylation UV-damage Excision Repair Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Viral Release From Host Cell MAPK Cascade Organelle Organization Positive Regulation Of Phosphorylation Cellular Protein Modification Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Protein Modification Process Regulation Of Binding Regulation Of Intracellular Protein Transport Histone H3-K9 Trimethylation Peptidyl-amino Acid Modification Activation Of Protein Kinase Activity Peptidyl-lysine Dimethylation Histone H2A Monoubiquitination Signal Transduction By Phosphorylation Response To Hypoxia Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Metabolic Process Histone H2A Ubiquitination Regulation Of Protein Phosphorylation Chromatin Silencing At RDNA Regulation Of SMAD Protein Import Into Nucleus	Cellular Response To Stress Cellular Metabolic Process Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cullin Deneddylation Nucleobase-containing Compound Metabolic Process Protein Ubiquitination DNA Repair Protein Deneddylation Heterocycle Metabolic Process Protein Modification By Small Protein Conjugation Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Protein Modification By Small Protein Removal Nitrogen Compound Metabolic Process Response To UV Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Protein Monoubiquitination Immune System Development Cellular Response To Stimulus Metabolic Process Catabolic Process Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Response To Radiation Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Process Regulation Of Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Light Stimulus Nucleotide-excision Repair Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Nitrogen Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Protein Metabolic Process Cellular Protein Catabolic Process Embryo Development Ending In Birth Or Egg Hatching
Tagcloud ?			accordingly adaptor arabidopsis atgenexpress crl4 cullin4 dhu1 doses downregulated dwd e3 exhibits hypersensitive hypersensitivity hypocotyl hypocotyls illumination implying insertion ligase mumol named responsiveness substrate times ultraviolet upregulated uv visualization
Tagcloud (Difference) ?			accordingly adaptor arabidopsis atgenexpress crl4 cullin4 dhu1 doses downregulated dwd e3 exhibits hypersensitive hypersensitivity hypocotyl hypocotyls illumination implying insertion ligase mumol named responsiveness substrate times ultraviolet upregulated uv visualization
Tagcloud (Intersection) ?