DCAF8 and PRMT8

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		DCAF8	PRMT8
Description		DDB1 and CUL4 associated factor 8	protein arginine methyltransferase 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Histone H4 Methyltransferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Myotube Cell Development Protein Ubiquitination	Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Methylation Peptidyl-arginine Methylation Methylation Protein Homooligomerization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Pathways		Neddylation
Drugs
Diseases
GWAS		Breast size ( 27182965) Lung function (FEV1/FVC) ( 30061609) Squamous cell lung carcinoma ( 28604730)	Cardiac Troponin-T levels ( 31014085) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) HDL cholesterol ( 19060911)
Interacting Genes		17 interacting genes: CRYAA DDB1 GSK3A GTPBP3 MDFI PIK3R3 PRMT1 PRMT8 RAF1 RBM11 RBPMS SPAST SUV39H1 THAP1 TNS2 TRIM54 WDR76	20 interacting genes: CARM1 CEP162 COIL DCAF8 FBL FYN GPATCH2L H4C1 KRTAP6-3 OFCC1 PIK3R1 PLCG1 PPARA PRMT1 PRMT2 SERBP1 TNPO2 UBL5 VHL ZNF451
Entrez ID		50717	56341
HPRD ID		18300	11029
Ensembl ID		ENSG00000132716	ENSG00000111218
Uniprot IDs		B7Z8C9 Q5TAQ9	Q59GT2 Q9NR22
PDB IDs		3I8E	4X41 5DST
Enriched GO Terms of Interacting Partners?		Epigenetic Programming Of Gene Expression Protein-arginine Omega-N Monomethyltransferase Activity Histone Methyltransferase Activity Peptidyl-arginine Methylation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone H4 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Methylation Insulin Receptor Signaling Pathway Epigenetic Programming In The Zygotic Pronuclei Identical Protein Binding Nucleus S-adenosyl-L-methionine Binding Macromolecule Methylation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Viral Protein Processing S-adenosylmethionine-dependent Methyltransferase Activity Viral Process Developmental Process Regulation Of Microtubule Cytoskeleton Organization Enzyme Binding Protein Methylation Methyltransferase Activity Regulation Of Microtubule Depolymerization Cellular Developmental Process Protein-containing Complex Assembly Negative Regulation Of UDP-glucose Catabolic Process Cell Differentiation Protein Homooligomerization GATOR1 Complex Binding Chromatin Organization Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus RNA Processing Regulation Of Macromolecule Metabolic Process Heterochromatin Response To Stress Protein-containing Complex Organization Negative Regulation Of Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Protein Complex Oligomerization Death-inducing Signaling Complex Assembly TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Regulation Of Microtubule-based Process Regulation Of Alternative MRNA Splicing, Via Spliceosome	Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone Methyltransferase Activity Neurotrophin TRKA Receptor Binding Methyltransferase Activity Cajal Body Nucleus Negative Regulation Of Inflammatory Response Methylation Negative Regulation Of Developmental Process Protein Methyltransferase Activity Phosphatidylinositol 3-kinase Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Macromolecule Methylation Negative Regulation Of Defense Response Protein Modification Process Nucleoplasm Chromatin Remodeling U6 SnRNA 2'-O-ribose Methyltransferase Activity Regulation Of Apoptotic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Glycine Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Singlet Oxygen Protein Methylation Histone H3R8 Methyltransferase Activity GATOR1 Complex Binding Negative Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transformation Of Host Cell By Virus Regulation Of Developmental Process Regulation Of Programmed Cell Death DNA-binding Transcription Factor Binding Regulation Of Inflammatory Response
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