TRIM55 and TNNI2

Number of citations of the paper that reports this interaction (PMID 18157088)
41

Data Source:
BioGRID (two hybrid)

		TRIM55	TNNI2
Gene Name		tripartite motif containing 55	troponin I type 2 (skeletal, fast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule	Nucleus Cytosol Troponin Complex
	Molecular Function	Signal Transducer Activity Zinc Ion Binding Identical Protein Binding	Actin Binding Protein Binding Troponin T Binding
	Biological Process	Signal Transduction	Skeletal Muscle Contraction Regulation Of Muscle Contraction Muscle Filament Sliding Positive Regulation Of Transcription, DNA-templated
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS		Response to statin therapy ( 22666496)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		61 interactors: ACTA1 ANKRD1 ATP5B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1	13 interactors: ACTB CALM1 ESRRA HNF4G PKD2L1 RORB TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2
Entrez ID		84675	7136
HPRD ID		05927	01843
Ensembl ID		ENSG00000147573	ENSG00000130598
Uniprot IDs		Q9BYV6	P48788
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Protein Deubiquitination Protein Modification By Small Protein Removal Actin Filament-based Movement Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Muscle Contraction Actin Filament-based Process Cellular Protein Catabolic Process Protein Catabolic Process Muscle System Process Protein K48-linked Deubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Striated Muscle Cell Development Cellular Protein Metabolic Process Muscle Structure Development Muscle Cell Development Protein K63-linked Deubiquitination Myofibril Assembly Proteolysis Cellular Protein Modification Process Striated Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Development Muscle Tissue Morphogenesis Actomyosin Structure Organization Muscle Organ Morphogenesis Cardiac Muscle Tissue Development Protein Metabolic Process Muscle Organ Development Protein Modification By Small Protein Conjugation Muscle Cell Differentiation Myosin Filament Assembly Catabolic Process Actin Cytoskeleton Organization Skeletal Muscle Thin Filament Assembly Cytoskeleton Organization Skeletal Myofibril Assembly Response To Muscle Stretch Heart Morphogenesis Striated Muscle Contraction Cellular Process	Muscle Contraction Skeletal Muscle Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Muscle System Process Musculoskeletal Movement Actin-mediated Cell Contraction Regulation Of Muscle Contraction Actin Filament-based Movement Striated Muscle Contraction Cellular Response To Steroid Hormone Stimulus Response To Steroid Hormone Steroid Hormone Mediated Signaling Pathway Cellular Response To Organic Cyclic Compound Hormone-mediated Signaling Pathway Response To Lipid Cellular Response To Lipid Response To Organic Cyclic Compound Response To Hormone Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Hormone Stimulus Regulation Of ATPase Activity DNA-templated Transcription, Initiation Actin Filament-based Process Neural Nucleus Development Organ Development Regulation Of Muscle Filament Sliding Speed Movement Of Cell Or Subcellular Component Regulation Of Striated Muscle Contraction Midbrain Development Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Muscle Filament Sliding Diaphragm Contraction Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Osteoblast Differentiation Cellular Response To Organic Substance Signal Transduction Amacrine Cell Differentiation Regulation Of High Voltage-gated Calcium Channel Activity Sensory Perception Of Sour Taste Involuntary Skeletal Muscle Contraction System Development Skeletal Muscle Atrophy Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Glucocorticoid
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