TRIM55 and DCAF6

Number of citations of the paper that reports this interaction (PMID 18157088)
41

Data Source:
BioGRID (two hybrid)

		TRIM55	DCAF6
Gene Name		tripartite motif containing 55	DDB1 and CUL4 associated factor 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Signal Transducer Activity Zinc Ion Binding Identical Protein Binding	Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Signal Transduction	Protein Ubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS		Response to statin therapy ( 22666496)	Schizophrenia ( 22037555)
Protein-Protein Interactions		61 interactors: ACTA1 ANKRD1 ATP5B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1	9 interactors: ACVR1 AR BMPR1B NR3C1 SMAD2 SUPT5H TGFBR1 TRIM55 TRIM63
Entrez ID		84675	55827
HPRD ID		05927	17156
Ensembl ID		ENSG00000147573	ENSG00000143164
Uniprot IDs		Q9BYV6	Q58WW2
PDB IDs			3I7O
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Protein Deubiquitination Protein Modification By Small Protein Removal Actin Filament-based Movement Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Muscle Contraction Actin Filament-based Process Cellular Protein Catabolic Process Protein Catabolic Process Muscle System Process Protein K48-linked Deubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Striated Muscle Cell Development Cellular Protein Metabolic Process Muscle Structure Development Muscle Cell Development Protein K63-linked Deubiquitination Myofibril Assembly Proteolysis Cellular Protein Modification Process Striated Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Development Muscle Tissue Morphogenesis Actomyosin Structure Organization Muscle Organ Morphogenesis Cardiac Muscle Tissue Development Protein Metabolic Process Muscle Organ Development Protein Modification By Small Protein Conjugation Muscle Cell Differentiation Myosin Filament Assembly Catabolic Process Actin Cytoskeleton Organization Skeletal Muscle Thin Filament Assembly Cytoskeleton Organization Skeletal Myofibril Assembly Response To Muscle Stretch Heart Morphogenesis Striated Muscle Contraction Cellular Process	Activin Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Lipid Response To Organic Cyclic Compound Cellular Response To Steroid Hormone Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Urogenital System Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Lipid Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Organ Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Pharyngeal System Development Response To Steroid Hormone Pattern Specification Process Response To Glucocorticoid Negative Regulation Of Signal Transduction Regulation Of Gene Expression Response To Corticosteroid Response To Cholesterol Transcription Initiation From RNA Polymerase II Promoter Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Hormone Stimulus Signal Transduction Mesenchyme Development Reproductive Process DNA-templated Transcription, Initiation Response To Stimulus Signaling Cell Communication Regulation Of Apoptotic Process Stem Cell Development Developmental Process Involved In Reproduction Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Metabolic Process
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