TRIM55 and MYBPC3

Number of citations of the paper that reports this interaction (PMID 18157088)
41

Data Source:
BioGRID (two hybrid)

		TRIM55	MYBPC3
Gene Name		tripartite motif containing 55	myosin binding protein C, cardiac
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere A Band
	Molecular Function	Signal Transducer Activity Zinc Ion Binding Identical Protein Binding	ATPase Activator Activity Actin Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction	Regulation Of Heart Rate Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Muscle Filament Sliding Myosin Filament Assembly Positive Regulation Of ATPase Activity Regulation Of Muscle Filament Sliding Sarcomere Organization Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction
Drugs
Diseases
GWAS		Response to statin therapy ( 22666496)
Protein-Protein Interactions		61 interactors: ACTA1 ANKRD1 ATP5B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1	7 interactors: CAPN1 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN
Entrez ID		84675	4607
HPRD ID		05927	02980
Ensembl ID		ENSG00000147573	ENSG00000134571
Uniprot IDs		Q9BYV6	A5YM48 Q14896
PDB IDs			1GXE 1PD6 2AVG 2K1M 2V6H 3CX2
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Protein Deubiquitination Protein Modification By Small Protein Removal Actin Filament-based Movement Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Muscle Contraction Actin Filament-based Process Cellular Protein Catabolic Process Protein Catabolic Process Muscle System Process Protein K48-linked Deubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Striated Muscle Cell Development Cellular Protein Metabolic Process Muscle Structure Development Muscle Cell Development Protein K63-linked Deubiquitination Myofibril Assembly Proteolysis Cellular Protein Modification Process Striated Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Development Muscle Tissue Morphogenesis Actomyosin Structure Organization Muscle Organ Morphogenesis Cardiac Muscle Tissue Development Protein Metabolic Process Muscle Organ Development Protein Modification By Small Protein Conjugation Muscle Cell Differentiation Myosin Filament Assembly Catabolic Process Actin Cytoskeleton Organization Skeletal Muscle Thin Filament Assembly Cytoskeleton Organization Skeletal Myofibril Assembly Response To Muscle Stretch Heart Morphogenesis Striated Muscle Contraction Cellular Process	Actin Filament-based Movement Actomyosin Structure Organization Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Directional Locomotion Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Platelet Activation Uropod Organization Establishment Of Meiotic Spindle Localization Myosin Filament Assembly Establishment Of T Cell Polarity Respiratory Burst Involved In Defense Response Skeletal Muscle Atrophy Response To Yeast Muscle Contraction Striated Muscle Cell Differentiation Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Muscle Atrophy Killing By Host Of Symbiont Cells Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Muscle System Process Skeletal Muscle Adaptation Hydrogen Peroxide Biosynthetic Process Meiotic Spindle Organization Muscle Cell Differentiation Respiratory Burst Receptor Catabolic Process Negative Regulation Of Smooth Muscle Contraction Adult Heart Development Superoxide Anion Generation Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Myoblast Fusion Neutrophil Mediated Immunity Blood Coagulation Hemostasis Negative Regulation Of Muscle Contraction Platelet Formation Platelet Morphogenesis Cardiac Myofibril Assembly Killing Of Cells Of Other Organism Proteolysis Cardiac Muscle Hypertrophy Mitotic Chromosome Condensation
Tagcloud ?			11p11 28x10 38x 73x10 a1 acp2 allele attenuate chr11 encompassing epidemiology fasting fi forkhead foxa1 hepatoma hg18 influencing intron jointly kernel lies madd nr1h3 rare rs10838687 rs7944584 spi1 variants
Tagcloud (Difference) ?			11p11 28x10 38x 73x10 a1 acp2 allele attenuate chr11 encompassing epidemiology fasting fi forkhead foxa1 hepatoma hg18 influencing intron jointly kernel lies madd nr1h3 rare rs10838687 rs7944584 spi1 variants
Tagcloud (Intersection) ?