TRIM55 and OTUB2

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		TRIM55	OTUB2
Gene Name		tripartite motif containing 55	OTU deubiquitinase, ubiquitin aldehyde binding 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule	Nucleus
	Molecular Function	Signal Transducer Activity Zinc Ion Binding Identical Protein Binding	Ubiquitin-specific Protease Activity
	Biological Process	Signal Transduction	Proteolysis Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS		Response to statin therapy ( 22666496)
Protein-Protein Interactions		61 interactors: ACTA1 ANKRD1 ATP5B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1	33 interactors: APP ARRDC3 CPSF6 FAM168A KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 PJA1 RBCK1 REL RFFL RNF126 SIAH1 TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 UBC UBE2N USP21 USP28
Entrez ID		84675	78990
HPRD ID		05927	07620
Ensembl ID		ENSG00000147573	ENSG00000089723
Uniprot IDs		Q9BYV6	Q96DC9
PDB IDs			1TFF 4FJV
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Protein Deubiquitination Protein Modification By Small Protein Removal Actin Filament-based Movement Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Muscle Contraction Actin Filament-based Process Cellular Protein Catabolic Process Protein Catabolic Process Muscle System Process Protein K48-linked Deubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Striated Muscle Cell Development Cellular Protein Metabolic Process Muscle Structure Development Muscle Cell Development Protein K63-linked Deubiquitination Myofibril Assembly Proteolysis Cellular Protein Modification Process Striated Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Development Muscle Tissue Morphogenesis Actomyosin Structure Organization Muscle Organ Morphogenesis Cardiac Muscle Tissue Development Protein Metabolic Process Muscle Organ Development Protein Modification By Small Protein Conjugation Muscle Cell Differentiation Myosin Filament Assembly Catabolic Process Actin Cytoskeleton Organization Skeletal Muscle Thin Filament Assembly Cytoskeleton Organization Skeletal Myofibril Assembly Response To Muscle Stretch Heart Morphogenesis Striated Muscle Contraction Cellular Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Viral Release From Host Cell Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Negative Regulation Of Viral Entry Into Host Cell Regulation Of Signal Transduction Protein Polyubiquitination Regulation Of Viral Entry Into Host Cell Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Cellular Protein Modification Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Cytokine Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Immune Response Defense Response Regulation Of Viral Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Locomotion Immune System Process I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interferon-gamma Signal Transduction Regulation Of Locomotion Response To Interferon-gamma Negative Regulation Of Viral Transcription Protein Metabolic Process Signaling Regulation Of Cellular Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Tagcloud ?			antiviral attenuation coimmunoprecipitations deubiquitinating deubiquitination e3 emerged enzymes ifn ifnb1 induction interacted interferon irf3 knockdown ligases negatively opposite otub1 regulate regulators regulatory traf3 traf6 translational triggered ubiquitin ubiquitination virus
Tagcloud (Difference) ?			antiviral attenuation coimmunoprecipitations deubiquitinating deubiquitination e3 emerged enzymes ifn ifnb1 induction interacted interferon irf3 knockdown ligases negatively opposite otub1 regulate regulators regulatory traf3 traf6 translational triggered ubiquitin ubiquitination virus
Tagcloud (Intersection) ?