DPY30 and KMT2C

Number of citations of the paper that reports this interaction (PubMedID 26324722)
56

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		DPY30	KMT2C
Description		dpy-30 histone methyltransferase complex regulatory subunit	lysine methyltransferase 2C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Acyltransferase Activity Histone Methyltransferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Chromatin Organization Endosomal Transport Transcription Initiation-coupled Chromatin Remodeling	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19	14 interacting genes: APPL2 DPY30 H2AC4 H2BC3 H3-4 H3C1 H3C14 H4C1 JUN MAPK14 MTNR1B RNF10 SMARCB1 TSC22D1
Entrez ID		84661	58508
HPRD ID		17434	06016
Ensembl ID		ENSG00000162961	ENSG00000055609
Uniprot IDs		Q9C005	Q8NEZ4
PDB IDs		3G36 4RIQ 4RT4 4RTA 6E2H 6PWV 7UD5	2YSM 2YUK 3UVL 4ERY 5F59 5F6K 6KIW 6MLC 7W6L
Enriched GO Terms of Interacting Partners?		Set1C/COMPASS Complex Gonadal Mesoderm Development Histone Methyltransferase Complex Chromatin Remodeling Nucleosome Assembly Nucleosome Organization Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Chromatin Organization Mesoderm Development Mesenchyme Development MLL3/4 Complex Histone H3K4 Methyltransferase Activity Proteasome Accessory Complex Protein-DNA Complex Assembly Midbody Abscission Beta-catenin Binding Protein Kinase A Regulatory Subunit Binding Mitotic Cytokinetic Process 9+2 Motile Cilium Axoneme	Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Protein-DNA Complex Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Protein Heterodimerization Activity Protein-containing Complex Assembly Protein-containing Complex Organization DNA Binding Chromosome Negative Regulation Of Cell Population Proliferation Nucleus Regulation Of Cell Development Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Host-mediated Activation Of Viral Transcription CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Cell Population Proliferation Response To Muscle Stretch Cellular Component Assembly Host-mediated Perturbation Of Viral Transcription Nuclear Chromosome Regulation Of Hemopoiesis Chromosome, Telomeric Region Host-mediated Activation Of Viral Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Localization To Chromosome, Centromeric Region Regulation Of Multicellular Organismal Development Positive Regulation Of Myoblast Differentiation Regulation Of Gene Expression Transcription Initiation-coupled Chromatin Remodeling Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Protein Localization To Chromatin Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression, Epigenetic Regulation Of Macromolecule Biosynthetic Process Regulation Of D-glucose Import Nucleoplasm Negative Regulation Of Cell Development Regulation Of Developmental Process Leading Edge Cell Differentiation Positive Regulation Of Macropinocytosis Regulation Of D-glucose Transmembrane Transport Regulation Of Myoblast Differentiation Host-mediated Perturbation Of Viral Process Negative Regulation Of Cell Differentiation
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