DPY30 and PSMD14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		DPY30	PSMD14
Description		dpy-30 histone methyltransferase complex regulatory subunit	proteasome 26S subunit, non-ATPase 14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Lid Subcomplex Proteasome Accessory Complex Cytosolic Proteasome Complex Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding Endopeptidase Activator Activity K63-linked Deubiquitinase Activity Proteasome Binding Metal-dependent Deubiquitinase Activity
	Biological Process	Chromatin Organization Endosomal Transport Transcription Initiation-coupled Chromatin Remodeling	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Ethanol Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination
Pathways		PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Educational attainment ( 25201988) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990)
Interacting Genes		33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19	12 interacting genes: ADRM1 CEBPA DPY30 FAM9B FILNC1 IRF3 MEOX2 MITF OLIG1 TGFBR2 UBC ZBTB7A
Entrez ID		84661	10213
HPRD ID		17434	06208
Ensembl ID		ENSG00000162961	ENSG00000115233
Uniprot IDs		Q9C005	A0A140VKF2 O00487
PDB IDs		3G36 4RIQ 4RT4 4RTA 6E2H 6PWV 7UD5	5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Set1C/COMPASS Complex Gonadal Mesoderm Development Histone Methyltransferase Complex Chromatin Remodeling Nucleosome Assembly Nucleosome Organization Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Chromatin Organization Mesoderm Development Mesenchyme Development MLL3/4 Complex Histone H3K4 Methyltransferase Activity Proteasome Accessory Complex Protein-DNA Complex Assembly Midbody Abscission Beta-catenin Binding Protein Kinase A Regulatory Subunit Binding Mitotic Cytokinetic Process 9+2 Motile Cilium Axoneme	DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Leukocyte Differentiation Myeloid Leukocyte Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Myeloid Cell Differentiation Sequence-specific Double-stranded DNA Binding E-box Binding Cell Proliferation Involved In Endocardial Cushion Morphogenesis Positive Regulation Of Tolerance Induction To Self Antigen Superior Endocardial Cushion Morphogenesis SMAD Binding Inferior Endocardial Cushion Morphogenesis DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Initiation Mononuclear Cell Differentiation Response To Vitamin B2 C/EBP Complex Positive Regulation Of Transcription By RNA Polymerase II Roof Of Mouth Development Melanocyte Apoptotic Process Bronchus Morphogenesis Transforming Growth Factor Beta Receptor Activity, Type II Positive Regulation Of B Cell Tolerance Induction Mammary Gland Morphogenesis Nucleus Regulation Of DNA-templated Transcription Initiation Regulation Of Stem Cell Proliferation DNA Binding CHOP-C/EBP Complex Macrophage Apoptotic Process Growth Plate Cartilage Chondrocyte Growth Bronchus Development Transforming Growth Factor Beta Ligand-receptor Complex MiRNA Transport Notch Signaling Pathway Lung Development Cell Development Nucleobase-containing Compound Biosynthetic Process White Fat Cell Proliferation MDA-5 Signaling Pathway Langerhans Cell Differentiation Type III Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Tricuspid Valve Morphogenesis Positive Regulation Of NK T Cell Differentiation
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