DPY30 and BEND3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DPY30	BEND3
Description		dpy-30 histone methyltransferase complex regulatory subunit	BEN domain containing 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Heterochromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	RDNA Binding DNA Binding Protein Binding
	Biological Process	Chromatin Organization Endosomal Transport Transcription Initiation-coupled Chromatin Remodeling	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Protein Homooligomerization Positive Regulation Of ATP Metabolic Process
Pathways		PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs
Diseases
GWAS		Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Brain morphology (MOSTest) ( 32665545) Hip index ( 34021172) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental longevity (combined parental age at death) ( 29227965) Postprandial triglyceride response to high fat diet meal ( 26256467) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969)
Interacting Genes		33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19	5 interacting genes: DPY30 FAM161A MCRS1 MORN4 UBTFL1
Entrez ID		84661	57673
HPRD ID		17434	18934
Ensembl ID		ENSG00000162961	ENSG00000178409
Uniprot IDs		Q9C005	Q5T5X7
PDB IDs		3G36 4RIQ 4RT4 4RTA 6E2H 6PWV 7UD5	5JNO 7W27
Enriched GO Terms of Interacting Partners?		Set1C/COMPASS Complex Gonadal Mesoderm Development Histone Methyltransferase Complex Chromatin Remodeling Nucleosome Assembly Nucleosome Organization Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Chromatin Organization Mesoderm Development Mesenchyme Development MLL3/4 Complex Histone H3K4 Methyltransferase Activity Proteasome Accessory Complex Protein-DNA Complex Assembly Midbody Abscission Beta-catenin Binding Protein Kinase A Regulatory Subunit Binding Mitotic Cytokinetic Process 9+2 Motile Cilium Axoneme	MLL1 Complex NSL Complex Poly(G) Binding Telomerase Inhibitor Activity Regulation Of DNA Strand Elongation Regulation Of Protein Localization To Nucleolus Positive Regulation Of Protein Localization To Nucleolus Ino80 Complex G-quadruplex RNA Binding Positive Regulation Of Telomere Maintenance In Response To DNA Damage Astral Microtubule Set1C/COMPASS Complex MLL1/2 Complex MLL3/4 Complex Stereocilium Tip Actin-based Cell Projection Transcription By RNA Polymerase I RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Blastocyst Growth RNA Polymerase I Preinitiation Complex Assembly Filopodium Tip
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