DPY30 and AKAP14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DPY30	AKAP14
Description		dpy-30 histone methyltransferase complex regulatory subunit	A-kinase anchoring protein 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Trans-Golgi Network Histone Methyltransferase Complex MLL1/2 Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Cytoplasm Axoneme CAMP-dependent Protein Kinase Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Chromatin Organization Endosomal Transport Transcription Initiation-coupled Chromatin Remodeling
Pathways		PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
Drugs
Diseases
GWAS		Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		33 interacting genes: AK8 AKAP14 ARFGEF1 ASH2L BCAS4 BEND3 CDK17 CFAP91 CHMP2B CREB3L3 DYDC1 DYDC2 FAM136A GPATCH2 GTF2I H3-4 ICA1L KMT2C MRFAP1 OTX1 PRPF3 PRRC2B PSMC3 PSMD14 PXN RSPH3 SETD1A TMCC2 TSPY10 TSPY2 TSPY3 UBC ZFYVE19	8 interacting genes: DPY30 FBXO7 PRKACA PRKAR1B PRKAR2A PRKAR2B ROPN1 ROPN1L
Entrez ID		84661	158798
HPRD ID		17434	02353
Ensembl ID		ENSG00000162961	ENSG00000186471
Uniprot IDs		Q9C005	Q86UN6
PDB IDs		3G36 4RIQ 4RT4 4RTA 6E2H 6PWV 7UD5
Enriched GO Terms of Interacting Partners?		Set1C/COMPASS Complex Gonadal Mesoderm Development Histone Methyltransferase Complex Chromatin Remodeling Nucleosome Assembly Nucleosome Organization Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Chromatin Organization Mesoderm Development Mesenchyme Development MLL3/4 Complex Histone H3K4 Methyltransferase Activity Proteasome Accessory Complex Protein-DNA Complex Assembly Midbody Abscission Beta-catenin Binding Protein Kinase A Regulatory Subunit Binding Mitotic Cytokinetic Process 9+2 Motile Cilium Axoneme	CAMP-dependent Protein Kinase Complex Ciliary Base CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Sperm Capacitation CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Negative Regulation Of Intracellular Signal Transduction Nucleotide-activated Protein Kinase Complex Cell Maturation Developmental Maturation Motile Cilium Plasma Membrane Raft Protein Domain Specific Binding Postsynapse Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication G Protein-coupled Receptor Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Intracellular Signal Transduction Protein Kinase Binding Response To Antipsychotic Drug Modulation Of Chemical Synaptic Transmission Axoneme Lewy Body Core Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Cilium Glutamatergic Synapse Centrosome CAMP-dependent Protein Kinase Activity Cilium Movement Channel Activator Activity Regulation Of Macroautophagy Positive Regulation Of Fear Response CAMP/PKA Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
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