GLYR1 and WHSC1L1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		GLYR1	WHSC1L1
Gene Name		glyoxylate reductase 1 homolog (Arabidopsis)	Wolf-Hirschhorn syndrome candidate 1-like 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus	Nucleus Nucleoplasm Chromosome
	Molecular Function	DNA Binding Phosphogluconate Dehydrogenase (decarboxylating) Activity Methylated Histone Binding NAD Binding	Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K4 Specific) Histone Methyltransferase Activity (H3-K27 Specific)
	Biological Process	Pentose-phosphate Shunt	Chromatin Organization Transcription, DNA-templated Histone Methylation Negative Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation Histone H3-K27 Methylation
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Schizophrenia ( 22037555)
Protein-Protein Interactions		8 interactors: C6orf165 CCNC EIF1AD FHL2 GEMIN4 HIST3H3 KDM1A WHSC1L1	17 interactors: CBX3 CBX5 DAXX DOCK7 ETV3 GLYR1 H3F3C HIST1H1A HOXC4 MLLT6 MNDA SEPT6 SLU7 SPAG8 STAC3 UBE2I ZNF557
Entrez ID		84656	54904
HPRD ID		17625	06155
Ensembl ID		ENSG00000140632	ENSG00000147548
Uniprot IDs		Q49A26	B7ZL11 Q9BZ95
PDB IDs		2UYY 4GUR 4GUS 4GUT 4GUU 4HSU	2DAQ 4GND 4GNE 4GNF 4GNG
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Primitive Erythrocyte Differentiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Atrial Cardiac Muscle Cell Development Nitrogen Compound Metabolic Process Muscle Cell Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Transcription, DNA-templated Chromosome Organization Histone H3-K27 Methylation Cellular Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Hormone Biosynthetic Process Muscle Cell Differentiation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Heart Trabecula Formation Granulocyte Differentiation Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Histone Modification Regulation Of Megakaryocyte Differentiation Ventricular Cardiac Muscle Cell Development Negative Regulation Of Histone Methylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Hormone Biosynthetic Process Heart Trabecula Morphogenesis	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Cell Division Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Viral Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Establishment Of Neuroblast Polarity Cytokinesis Nucleosome Assembly MRNA 3'-splice Site Recognition Transcription, DNA-templated Chromatin Assembly RNA Metabolic Process RNA Biosynthetic Process Regulation Of Metabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Gene Expression Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Chromatin Remodeling DNA Packaging Nucleobase-containing Compound Metabolic Process
Tagcloud ?		catalytic catalyzed characterization characterize cofactor crystal define demethylases demethylation determinants dodecapeptide dynamic epigenetic establish eukaryotic fundamental h3k4 h3k4me1 h3k4me2 intrinsic kdm1b linker lsd2 minimal npac represents resolutions stimulates stimulating	aside c5hch cys dimethylase fifth h3k36 h3k4 h3k9 h3k9me0 h3k9me3 homeodomain k9 k9me3 methyltransferases mmset module mono nonredundant nsd nsd1 nsd2 nsd3 phd phd5 shed trimethylated unmethylated unmodified
Tagcloud (Difference) ?		catalytic catalyzed characterization characterize cofactor crystal define demethylases demethylation determinants dodecapeptide dynamic epigenetic establish eukaryotic fundamental h3k4me1 h3k4me2 intrinsic kdm1b linker lsd2 minimal npac represents resolutions stimulates stimulating	aside c5hch cys dimethylase fifth h3k36 h3k9 h3k9me0 h3k9me3 homeodomain k9 k9me3 methyltransferases mmset module mono nonredundant nsd nsd1 nsd2 nsd3 phd phd5 shed trimethylated unmethylated unmodified
Tagcloud (Intersection) ?		h3k4