GLYR1 and CLIC3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		GLYR1	CLIC3
Name		glyoxylate reductase 1 homolog	chloride intracellular channel 3
Structure
GO Annotations	Cellular Component	Chromatin Nucleosome Nucleus Nucleoplasm Chromosome Cytosol	Extracellular Region Nucleus Cytoplasm Plasma Membrane Membrane Nuclear Body Extracellular Matrix Monoatomic Ion Channel Complex Chloride Channel Complex Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Nucleosome Binding Histone Binding NADP Binding NAD Binding Chromatin-protein Adaptor Activity	Chloride Channel Activity Protein Binding Oxidoreductase Activity Protein-disulfide Reductase (glutathione) Activity
	Biological Process	Transcription Initiation-coupled Chromatin Remodeling Transcription Elongation-coupled Chromatin Remodeling	Monoatomic Ion Transport Chloride Transport Signal Transduction Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Sprouting Angiogenesis
GWAS		Cancer ( 29299148 ) Night sleep phenotypes ( 27126917 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: GLIS2	None recorded
Interacting Genes		14 interacting genes: ARL16 CCNC CDKN2D CFAP206 CLIC3 EIF1AD FHL2 FXR1 GEMIN4 H3-4 H3C1 KDM1A NSD3 NTMT1	35 interacting genes: AGR2 ALX1 ANKRD23 ANKRD55 APP CIMIP2B DDIT4L DNM1 EFHC2 GLYR1 INCA1 KATNBL1 KRT85 KRTAP13-3 LELP1 MAPK15 MBD3L1 MECOM MIA3 MSX2 POT1 PROSER2 SCML4 SPMIP4 SPMIP6 STMN3 TBC1D3 TBC1D3C TBC1D3K TEPSIN TLE5 VPS4A ZBTB42 ZC2HC1C ZNF620
Entrez ID		84656	9022
HPRD ID		17625	05941
Ensembl ID		ENSG00000140632	ENSG00000169583
Uniprot IDs		Q49A26 Q9NZ78	O95833
PDB IDs		2UYY 4GUR 4GUS 4GUT 4GUU 4HSU 6R1U 6R25	3FY7 3KJY
GO Terms Enriched among Interactors		Nucleoplasm Nucleus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ribonucleoprotein Complex Binding Chromatin Remodeling Chromatin Organization N-terminal Protein N-methyltransferase Activity N-terminal Protein Amino Acid Methylation Histone Methyltransferase Activity N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-proline Dimethylation N-terminal Peptidyl-serine Trimethylation N-terminal Peptidyl-glycine Methylation Histone H3K4 Dimethyltransferase Activity Histone H3K27 Dimethyltransferase Activity A Axonemal Microtubule Atrial Cardiac Muscle Cell Development Protein-disulfide Reductase (glutathione) Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Cyclin D2-CDK4 Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Translational Initiation Chromosome Structural Constituent Of Chromatin Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone H3K27 Trimethyltransferase Activity	None