RHOXF2 and NANOG

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		RHOXF2	NANOG
Gene Name		Rhox homeobox family, member 2	Nanog homeobox
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Sequence-specific DNA Binding	Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity
	Biological Process	Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesodermal Cell Fate Commitment Endodermal Cell Fate Specification Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Proliferation Positive Regulation Of Cell Proliferation Gonad Development Embryonic Pattern Specification Negative Regulation Of Cell Fate Commitment Regulation Of Gene Expression Stem Cell Division Stem Cell Maintenance Cell Differentiation Negative Regulation Of BMP Signaling Pathway Response To Retinoic Acid Somatic Stem Cell Maintenance Regulation Of Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS
Protein-Protein Interactions		56 interactors: AES ARID5A ATN1 ATXN1 CCDC33 CCNK CHAC1 CLASRP CLDN7 CRYBA1 DAB1 DAZAP2 DEDD2 DTX2 DVL2 EFEMP2 EWSR1 FAM103A1 FAM46B FAM46C FAM46D FBF1 HNRNPLL HOXC13 KRTAP19-5 KRTAP19-7 LASP1 LENG8 LSM4 LZTS2 MAGED1 MED7 MVP NANOG NEU4 PITX1 PLOD3 POLR3D POU2AF1 PSMF1 RADIL RBFOX1 RBFOX2 RBM11 RBPMS SERF2 SNAPC1 SUMO1 TMCC2 TOLLIP TRIP13 UPF1 UTP6 VAC14 VPS25 ZBTB32	3 interactors: MED12 PRKCE RHOXF2
Entrez ID		84528	79923
HPRD ID		02345	06397
Ensembl ID		ENSG00000131721	ENSG00000111704
Uniprot IDs		Q9BQY4	Q9H9S0
PDB IDs			2KT0
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression MRNA Metabolic Process Cellular Metabolic Process MRNA Processing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Radial Glia Guided Migration Of Purkinje Cell Anatomical Structure Development Regulation Of RNA Splicing Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Developmental Process Regulation Of Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process RNA Splicing Negative Regulation Of Wnt Signaling Pathway Cellular Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Cell Migration In Hindbrain Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Signaling Positive Regulation Of Protein Modification Process	Positive Regulation Of Cellular Glucuronidation TRAM-dependent Toll-like Receptor 4 Signaling Pathway Axis Elongation Involved In Somitogenesis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Cellular Response To Ethanol Positive Regulation Of Fibroblast Migration Macrophage Activation Involved In Immune Response Locomotory Exploration Behavior Negative Regulation Of Sodium Ion Transport Positive Regulation Of Synaptic Transmission, GABAergic
Tagcloud ?		ba carcinogenesis cdna cloning expresses f3 focused gadd45b gastric glioma hf6 hgc27 homeobox irradiated libraries lines oncogenes pim quickly render rendered repressor reproductive retrovirus searched sublethally transduced transplanted	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nefl nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Difference) ?		ba carcinogenesis cdna cloning expresses f3 focused gadd45b gastric glioma hf6 hgc27 homeobox irradiated libraries lines oncogenes pim quickly render rendered repressor reproductive retrovirus searched sublethally transduced transplanted	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nefl nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Intersection) ?