NANOG and SPOP

Number of citations of the paper that reports this interaction (PubMedID 30595535)
57

Data Source:
BioGRID (unspecified method, imaging technique, affinity chromatography technology)

		NANOG	SPOP
Description		Nanog homeobox	speckle type BTB/POZ protein
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Molecular Function Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Stem Cell Population Maintenance Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Stem Cell Proliferation	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Germ layer formation at gastrulation Formation of the anterior neural plate Specification of primordial germ cells	Hedgehog 'on' state SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Interacting Genes		8 interacting genes: BRAF MED12 PRKCE RBPMS RHOXF2 SPOP TRRAP USP21	74 interacting genes: AEN AMOTL2 AR ATM BRAF BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 DAXX DDIT3 DHX15 DPPA2 DUSP7 EGLN2 ERF ERG FAF1 G3BP1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HIPK2 HMGCS1 ILF3 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NUDCD3 PDPK1 PDX1 PIAS1 PIAS3 PTEN RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TP53BP1 TPD52 TRAF1 TRAF6 TWIST1 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8
Entrez ID		79923	8405
HPRD ID		06397	16004
Ensembl ID		ENSG00000111704	ENSG00000121067
Uniprot IDs		A8K4D1 Q9H9S0	O43791
PDB IDs		2KT0 4RBO	2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D 7KLZ 7LIN 7LIO 7LIP 7LIQ 8DWS 8DWT 8DWU 8DWV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Fibroblast Migration Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Protein Modification Process Positive Regulation Of Biosynthetic Process Nucleus Somatic Stem Cell Population Maintenance Positive Regulation Of Macromolecule Metabolic Process Ethanol Binding Axis Elongation Involved In Somitogenesis Maintenance Of Cell Number Stem Cell Population Maintenance Positive Regulation Of Cell-substrate Adhesion TRAM-dependent Toll-like Receptor 4 Signaling Pathway Transcription Coregulator Activity	Nucleoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Positive Regulation Of Biosynthetic Process SUMO Transferase Activity Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Speck DNA-binding Transcription Factor Activity Regulation Of Signal Transduction Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Cellular Response To Stress Chromatin Organization Post-translational Protein Modification Regulation Of Programmed Cell Death Chromatin Remodeling Sequence-specific DNA Binding DNA Binding
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