NANOG and MED12

Number of citations of the paper that reports this interaction (PMID 19036726)
15

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		NANOG	MED12
Gene Name		Nanog homeobox	mediator complex subunit 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Nucleolus Centrosome Membrane Mediator Complex
	Molecular Function	Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Protein Domain Specific Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesodermal Cell Fate Commitment Endodermal Cell Fate Specification Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Proliferation Positive Regulation Of Cell Proliferation Gonad Development Embryonic Pattern Specification Negative Regulation Of Cell Fate Commitment Regulation Of Gene Expression Stem Cell Division Stem Cell Maintenance Cell Differentiation Negative Regulation Of BMP Signaling Pathway Response To Retinoic Acid Somatic Stem Cell Maintenance Regulation Of Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter	Neural Tube Closure Transcription Initiation From RNA Polymerase II Promoter Heart Development Gene Expression Oligodendrocyte Development Schwann Cell Development Stem Cell Maintenance Negative Regulation Of Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Axis Elongation Involved In Somitogenesis
Pathways		Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MED12 PRKCE RHOXF2	17 interactors: CDK8 ESR1 ESR2 GLI3 LYST MED1 MED13 MED26 MED29 MED8 MED9 MYC NANOG PPARGC1A SOX9 SREBF1 VDR
Entrez ID		79923	9968
HPRD ID		06397	02176
Ensembl ID		ENSG00000111704	ENSG00000184634
Uniprot IDs		Q9H9S0	Q93074
PDB IDs		2KT0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Glucuronidation TRAM-dependent Toll-like Receptor 4 Signaling Pathway Axis Elongation Involved In Somitogenesis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Cellular Response To Ethanol Positive Regulation Of Fibroblast Migration Macrophage Activation Involved In Immune Response Locomotory Exploration Behavior Negative Regulation Of Sodium Ion Transport Positive Regulation Of Synaptic Transmission, GABAergic	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gland Morphogenesis Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Response To Lipid Mammary Gland Branching Involved In Pregnancy Intracellular Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Tissue Morphogenesis Cellular Response To Lipid Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Morphogenesis Of An Epithelium Negative Regulation Of Gene Expression Mammary Gland Development Regulation Of Metabolic Process Response To Organic Substance Regulation Of Organ Morphogenesis Positive Regulation Of Cellular Metabolic Process Epithelial Tube Morphogenesis Regulation Of Cell Proliferation Mammary Gland Morphogenesis Tube Development Negative Regulation Of Transcription, DNA-templated Tube Morphogenesis
Tagcloud ?		abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nefl nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251	accounting actionable amplifications borderline cnas confined defines deleterious drive druggable exclusively expands ffpe fibroepithelial formalin g44 grades hotspot identifies landscape mutational neurofibromin nf1 ngs phyllodes rb1 retinoblastoma spanning suppressors
Tagcloud (Difference) ?		abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nefl nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251	accounting actionable amplifications borderline cnas confined defines deleterious drive druggable exclusively expands ffpe fibroepithelial formalin g44 grades hotspot identifies landscape mutational neurofibromin nf1 ngs phyllodes rb1 retinoblastoma spanning suppressors
Tagcloud (Intersection) ?