RHOXF2 and HOXC13

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		RHOXF2	HOXC13
Gene Name		Rhox homeobox family, member 2	homeobox C13
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated	Hair Follicle Development Transcription, DNA-templated Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Nail Development Tongue Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) ( 23648065) Biliary atresia ( 20460270) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		56 interactors: AES ARID5A ATN1 ATXN1 CCDC33 CCNK CHAC1 CLASRP CLDN7 CRYBA1 DAB1 DAZAP2 DEDD2 DTX2 DVL2 EFEMP2 EWSR1 FAM103A1 FAM46B FAM46C FAM46D FBF1 HNRNPLL HOXC13 KRTAP19-5 KRTAP19-7 LASP1 LENG8 LSM4 LZTS2 MAGED1 MED7 MVP NANOG NEU4 PITX1 PLOD3 POLR3D POU2AF1 PSMF1 RADIL RBFOX1 RBFOX2 RBM11 RBPMS SERF2 SNAPC1 SUMO1 TMCC2 TOLLIP TRIP13 UPF1 UTP6 VAC14 VPS25 ZBTB32	7 interactors: APEX1 ELF1 HNRNPAB HOXC9 MEIS1 NR2E3 RHOXF2
Entrez ID		84528	3229
HPRD ID		02345	00862
Ensembl ID		ENSG00000131721	ENSG00000123364
Uniprot IDs		Q9BQY4	P31276
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression MRNA Metabolic Process Cellular Metabolic Process MRNA Processing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Radial Glia Guided Migration Of Purkinje Cell Anatomical Structure Development Regulation Of RNA Splicing Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Developmental Process Regulation Of Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process RNA Splicing Negative Regulation Of Wnt Signaling Pathway Cellular Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Cell Migration In Hindbrain Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Signaling Positive Regulation Of Protein Modification Process	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Positive Regulation Of Rhodopsin Gene Expression Developmental Process Eye Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Rhodopsin Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Camera-type Eye Development Megakaryocyte Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Immune System Process Nucleotide-excision Repair, DNA Gap Filling Biosynthetic Process DNA Demethylation Negative Regulation Of Biosynthetic Process Cellular Response To Organic Cyclic Compound Eye Development Negative Regulation Of T Cell Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Organ Development Positive Regulation Of Cell Cycle G1/S Phase Transition Nuclear DNA Replication
Tagcloud ?		ba carcinogenesis cdna cloning expresses f3 focused gadd45b gastric glioma hf6 hgc27 homeobox irradiated libraries lines oncogenes pim quickly render rendered repressor reproductive retrovirus searched sublethally transduced transplanted	chip deep dysregulated dysregulation h3k27me3 homeobox hoxb7 hoxd8 irx1 irx4 keratinocytes mark neoplastic okf6 oncomine polycomb prc prc2 repressive rnaseq scc six2 suz12 tert1r transcripts tshz3 tumorigenic
Tagcloud (Difference) ?		ba carcinogenesis cdna cloning expresses f3 focused gadd45b gastric glioma hf6 hgc27 irradiated libraries lines oncogenes pim quickly render rendered repressor reproductive retrovirus searched sublethally transduced transplanted	chip deep dysregulated dysregulation h3k27me3 hoxb7 hoxd8 irx1 irx4 keratinocytes mark neoplastic okf6 oncomine polycomb prc prc2 repressive rnaseq scc six2 suz12 tert1r transcripts tshz3 tumorigenic
Tagcloud (Intersection) ?		homeobox