NANOG

Description		Nanog homeobox
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Stem Cell Population Maintenance Cell Differentiation Somatic Stem Cell Population Maintenance Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Stem Cell Proliferation
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Germ layer formation at gastrulation Formation of the anterior neural plate Specification of primordial germ cells
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: BRAF MED12 PRKCE RBPMS RHOXF2 SPOP TRRAP USP21
Entrez ID		79923
HPRD ID		06397
Ensembl ID		ENSG00000111704
Uniprot IDs		A8K4D1 Q9H9S0
PDB IDs		2KT0 4RBO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Fibroblast Migration Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Protein Modification Process Positive Regulation Of Biosynthetic Process Nucleus Somatic Stem Cell Population Maintenance Positive Regulation Of Macromolecule Metabolic Process Ethanol Binding Axis Elongation Involved In Somitogenesis Maintenance Of Cell Number Stem Cell Population Maintenance Positive Regulation Of Cell-substrate Adhesion TRAM-dependent Toll-like Receptor 4 Signaling Pathway Transcription Coregulator Activity
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