JAGN1 and TREX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		JAGN1	TREX1
Description		jagunal vesicle mediated transporter 1	three prime repair exonuclease 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Oligosaccharyltransferase Complex Membrane Protein-DNA Complex Nuclear Replication Fork
	Molecular Function	Protein Binding	Magnesium Ion Binding Nucleic Acid Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Nuclease Activity Exonuclease Activity DNA Exonuclease Activity Protein Binding 3'-5'-DNA Exonuclease Activity DNA Binding, Bending Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding WW Domain Binding
	Biological Process	Immune System Process Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Response To Glucose Protein Transport Vesicle-mediated Transport Insulin Secretion Neutrophil Differentiation Response To Endoplasmic Reticulum Stress Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Insulin Metabolic Process Neutrophil Migration	DNA Damage Checkpoint Signaling Blood Vessel Development Kidney Development Adaptive Immune Response Organ Or Tissue Specific Immune Response Activation Of Immune Response Macrophage Activation Involved In Immune Response Lymphoid Progenitor Cell Differentiation Immune Response In Brain Or Nervous System Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Regulation Of Immunoglobulin Production Heart Morphogenesis Heart Process Atrial Cardiac Muscle Tissue Development Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Modification DNA Catabolic Process DNA Recombination Inflammatory Response Immune Response DNA Damage Response Determination Of Adult Lifespan Response To UV Regulation Of Gene Expression Regulation Of Fatty Acid Metabolic Process Regulation Of Metabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Retrotransposition Regulation Of Type I Interferon Production Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Cellular Response To UV Cellular Response To Interferon-beta Apoptotic Cell Clearance Regulation Of Cellular Respiration Innate Immune Response Regulation Of Innate Immune Response Establishment Of Protein Localization Negative Regulation Of Innate Immune Response Regulation Of Lipid Biosynthetic Process Regulation Of Inflammatory Response Protein Stabilization Regulation Of T Cell Activation Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Cellular Response To Type I Interferon Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Immune Complex Formation CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway DNA Synthesis Involved In UV-damage Excision Repair Regulation Of Lysosome Organization
Pathways			Regulation by TREX1 IRF3-mediated induction of type I IFN
Drugs
Diseases			Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE) Aicardi-Goutieres Syndrome (AGS) Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Obesity-related traits ( 23251661) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		128 interacting genes: AGPAT4 APP AQP6 ARL13B ARLN BCL2L13 BET1 BMP10 BNIP1 BNIP3 BSND BTNL9 CALHM6 CCL4L2 CD79A CDIPT CERS4 CGRRF1 CLDN7 CLEC12B CLEC4D CLEC7A CMTM5 COX20 CREB3L1 CYBC1 CYP4F2 DNAJC30 EBP EDA2R EHHADH ELOVL4 ERG28 ERGIC3 F11R FAM177A1 FAM209A FCGR1A FCRL2 FCRL4 FDFT1 FIS1 FKBP8 FNDC9 FRMD3 FXYD6 GIMAP1 GIMAP5 GJB5 GOLM1 GOSR2 GP2 GPR152 GPR37L1 HMOX1 HSD17B13 HTATIP2 ICMT IER3IP1 IFNGR2 IL3RA KASH5 KCNA1 KIR2DL3 KIR3DL3 LEMD1 LHFPL5 LMNA LPAR3 MFF MRM3 MTIF3 NINJ2 NRG1 OTULINL PDZK1IP1 PLP1 PLPP2 PSCA RETREG3 RTP2 SACM1L SAR1A SCD SEC22B SERP1 SLAMF6 SLC10A6 SLC16A2 SLC23A2 SLC34A2 SMAGP SMIM1 SMIM19 SSMEM1 STOML3 STX1A STX3 STX5 STX7 STX8 TECR TIMM23 TMEM100 TMEM106C TMEM120B TMEM128 TMEM14B TMEM207 TMEM237 TMEM242 TMEM243 TMEM52B TMEM65 TMIE TNFSF14 TREX1 TSNARE1 UBE2J1 USE1 VAMP2 VAMP5 VAPA VAPB VKORC1 VMA12 VSIG4 VTI1B	48 interacting genes: AQP6 ATM ATR CD81 CHCHD2 CLDN22 CRB3 CYB561 CYSRT1 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR3 FNDC9 GJA5 GKN1 GPR42 HSD17B13 IFNGR2 IFT20 JAGN1 KRTAP10-7 MCM7 MSH2 NBN PEX12 PRKDC PRND RELL1 RIBC2 RNASEK RPA1 SEC11C SET SLC10A6 SLC22A2 SLC71A2 SLC7A14 TM4SF18 TMEM205 TMEM207 TMEM45B TMEM86B TMX2 UBQLN1 VKORC1
Entrez ID		84522	11277
HPRD ID		13749	09423
Ensembl ID		ENSG00000171135	ENSG00000213689
Uniprot IDs		Q8N5M9	Q5TZT0 Q9NSU2
PDB IDs		6WVD	7TQN 7TQO 7TQP 7TQQ 8VL7 9AVA
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNAP Receptor Activity Endoplasmic Reticulum SNARE Complex Membrane Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Vesicle Fusion Organelle Fusion Organelle Localization By Membrane Tethering Membrane Organization Golgi Vesicle Transport Membrane Docking Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endomembrane System Chloride Channel Inhibitor Activity Vesicle Docking Vesicle Organization Vesicle-mediated Transport Endoplasmic Reticulum Organization Plasma Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane External Side Of Plasma Membrane Establishment Of Protein Localization Cellular Localization Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex FFAT Motif Binding Lipid Biosynthetic Process Zymogen Granule Membrane Endoplasmic Reticulum-autophagosome Adaptor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Vesicle Positive Regulation Of Mitochondrial Fission Synaptic Vesicle COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization	Histone H2AXS139 Kinase Activity Membrane Chromosome, Telomeric Region Protein Localization To Site Of Double-strand Break Double-strand Break Repair Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere DNA Strand Resection Involved In Replication Fork Processing Somatic Cell DNA Recombination Positive Regulation Of Telomerase Catalytic Core Complex Assembly Telomere Maintenance DNA Damage Checkpoint Signaling Protein Localization To Chromosome DNA-dependent Protein Kinase Activity Telomere Organization Double-strand Break Repair Via Homologous Recombination Mitotic DNA Damage Checkpoint Signaling Recombinational Repair DNA Recombination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Somatic Recombination Of Immunoglobulin Gene Segments Protein Binding MutLalpha Complex Binding Negative Regulation Of Telomere Capping Somatic Diversification Of Immunoglobulins Double-strand Break Repair Via Alternative Nonhomologous End Joining Negative Regulation Of Mitotic Cell Cycle Protein Localization To Organelle Chromosome Organization Negative Regulation Of Cell Cycle Phase Transition Response To Gamma Radiation Mitotic G2/M Transition Checkpoint DNA Repair Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Telomere Capping Response To Ionizing Radiation Regulation Of Double-strand Break Repair Replicative Senescence Regulation Of Cellular Response To Heat DNA Replication Endoplasmic Reticulum Damaged DNA Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of DNA-templated DNA Replication Initiation DNA Metabolic Process Negative Regulation Of Cell Cycle Process Pexophagy Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
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