JAGN1 and SLAMF6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		JAGN1	SLAMF6
Description		jagunal vesicle mediated transporter 1	SLAM family member 6
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Immune System Process Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Response To Glucose Protein Transport Vesicle-mediated Transport Insulin Secretion Neutrophil Differentiation Response To Endoplasmic Reticulum Stress Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Insulin Metabolic Process Neutrophil Migration	Adaptive Immune Response Immune System Process Immune Response Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production T Cell Activation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity T-helper 17 Cell Lineage Commitment
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Graves' disease ( 23612905) Multiple sclerosis ( 24076602) Rheumatoid arthritis ( 32723749)
Interacting Genes		128 interacting genes: AGPAT4 APP AQP6 ARL13B ARLN BCL2L13 BET1 BMP10 BNIP1 BNIP3 BSND BTNL9 CALHM6 CCL4L2 CD79A CDIPT CERS4 CGRRF1 CLDN7 CLEC12B CLEC4D CLEC7A CMTM5 COX20 CREB3L1 CYBC1 CYP4F2 DNAJC30 EBP EDA2R EHHADH ELOVL4 ERG28 ERGIC3 F11R FAM177A1 FAM209A FCGR1A FCRL2 FCRL4 FDFT1 FIS1 FKBP8 FNDC9 FRMD3 FXYD6 GIMAP1 GIMAP5 GJB5 GOLM1 GOSR2 GP2 GPR152 GPR37L1 HMOX1 HSD17B13 HTATIP2 ICMT IER3IP1 IFNGR2 IL3RA KASH5 KCNA1 KIR2DL3 KIR3DL3 LEMD1 LHFPL5 LMNA LPAR3 MFF MRM3 MTIF3 NINJ2 NRG1 OTULINL PDZK1IP1 PLP1 PLPP2 PSCA RETREG3 RTP2 SACM1L SAR1A SCD SEC22B SERP1 SLAMF6 SLC10A6 SLC16A2 SLC23A2 SLC34A2 SMAGP SMIM1 SMIM19 SSMEM1 STOML3 STX1A STX3 STX5 STX7 STX8 TECR TIMM23 TMEM100 TMEM106C TMEM120B TMEM128 TMEM14B TMEM207 TMEM237 TMEM242 TMEM243 TMEM52B TMEM65 TMIE TNFSF14 TREX1 TSNARE1 UBE2J1 USE1 VAMP2 VAMP5 VAPA VAPB VKORC1 VMA12 VSIG4 VTI1B	11 interacting genes: BRICD5 CLDN19 CXCL14 JAGN1 PTPN11 PTPN6 RABAC1 SH2D1A TMBIM6 TMPPE ZAP70
Entrez ID		84522	114836
HPRD ID		13749	05920
Ensembl ID		ENSG00000171135	ENSG00000162739
Uniprot IDs		Q8N5M9	B4E1U5 Q96DU3
PDB IDs		6WVD	2IF7
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNAP Receptor Activity Endoplasmic Reticulum SNARE Complex Membrane Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Vesicle Fusion Organelle Fusion Organelle Localization By Membrane Tethering Membrane Organization Golgi Vesicle Transport Membrane Docking Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endomembrane System Chloride Channel Inhibitor Activity Vesicle Docking Vesicle Organization Vesicle-mediated Transport Endoplasmic Reticulum Organization Plasma Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane External Side Of Plasma Membrane Establishment Of Protein Localization Cellular Localization Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex FFAT Motif Binding Lipid Biosynthetic Process Zymogen Granule Membrane Endoplasmic Reticulum-autophagosome Adaptor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Vesicle Positive Regulation Of Mitochondrial Fission Synaptic Vesicle COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization	Phosphotyrosine Residue Binding Negative Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Leukocyte Mediated Immunity Immune Effector Process Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Killing Regulation Of T Cell Proliferation Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Negative Regulation Of Immune System Process Immune System Process Regulation Of T Cell Receptor Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Mononuclear Cell Proliferation T Cell Costimulation Myeloid Cell Differentiation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Positive Regulation Of T Cell Activation Cell Activation Epididymis Development Regulation Of Leukocyte Proliferation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Myeloid Cell Development Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Negative Regulation Of T Cell Proliferation Leukocyte Mediated Cytotoxicity Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Intestinal Epithelial Cell Migration Endoribonuclease Inhibitor Activity T Cell Aggregation Mesaxon Protein Dephosphorylation Negative Regulation Of Cell Communication
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