JAGN1 and FCGR1A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		JAGN1	FCGR1A
Description		jagunal vesicle mediated transporter 1	Fc gamma receptor Ia
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding IgG Receptor Activity High-affinity IgG Receptor Activity IgG Binding
	Biological Process	Immune System Process Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Response To Glucose Protein Transport Vesicle-mediated Transport Insulin Secretion Neutrophil Differentiation Response To Endoplasmic Reticulum Stress Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Insulin Metabolic Process Neutrophil Migration	Antibody-dependent Cellular Cytotoxicity Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Immune System Process Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Innate Immune Response Positive Regulation Of Phagocytosis Regulation Of Immune Response
Pathways			Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs			Cetuximab Etanercept Human immunoglobulin G Gemtuzumab ozogamicin Alemtuzumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Catumaxomab Sarilumab Trastuzumab deruxtecan
Diseases
GWAS
Interacting Genes		128 interacting genes: AGPAT4 APP AQP6 ARL13B ARLN BCL2L13 BET1 BMP10 BNIP1 BNIP3 BSND BTNL9 CALHM6 CCL4L2 CD79A CDIPT CERS4 CGRRF1 CLDN7 CLEC12B CLEC4D CLEC7A CMTM5 COX20 CREB3L1 CYBC1 CYP4F2 DNAJC30 EBP EDA2R EHHADH ELOVL4 ERG28 ERGIC3 F11R FAM177A1 FAM209A FCGR1A FCRL2 FCRL4 FDFT1 FIS1 FKBP8 FNDC9 FRMD3 FXYD6 GIMAP1 GIMAP5 GJB5 GOLM1 GOSR2 GP2 GPR152 GPR37L1 HMOX1 HSD17B13 HTATIP2 ICMT IER3IP1 IFNGR2 IL3RA KASH5 KCNA1 KIR2DL3 KIR3DL3 LEMD1 LHFPL5 LMNA LPAR3 MFF MRM3 MTIF3 NINJ2 NRG1 OTULINL PDZK1IP1 PLP1 PLPP2 PSCA RETREG3 RTP2 SACM1L SAR1A SCD SEC22B SERP1 SLAMF6 SLC10A6 SLC16A2 SLC23A2 SLC34A2 SMAGP SMIM1 SMIM19 SSMEM1 STOML3 STX1A STX3 STX5 STX7 STX8 TECR TIMM23 TMEM100 TMEM106C TMEM120B TMEM128 TMEM14B TMEM207 TMEM237 TMEM242 TMEM243 TMEM52B TMEM65 TMIE TNFSF14 TREX1 TSNARE1 UBE2J1 USE1 VAMP2 VAMP5 VAPA VAPB VKORC1 VMA12 VSIG4 VTI1B	31 interacting genes: ADIPOQ APCS ASGR1 BIK BMP10 CD163 CLDN19 CLEC7A CLIC6 CRKL CRP FAM3C FCAR FCGR3A HCK HRG ITM2A JAGN1 LAT LHFPL5 LILRB2 MALL NINJ1 NRSN1 RPRM SYK TNMD TSPO2 UPK2 VSTM1 VTI1B
Entrez ID		84522	2209
HPRD ID		13749	00904
Ensembl ID		ENSG00000171135	ENSG00000150337
Uniprot IDs		Q8N5M9	P12314
PDB IDs		6WVD	3RJD 4W4O 4X4M 4ZNE 8DIN 8DIR 8DJ7
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNAP Receptor Activity Endoplasmic Reticulum SNARE Complex Membrane Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Vesicle Fusion Organelle Fusion Organelle Localization By Membrane Tethering Membrane Organization Golgi Vesicle Transport Membrane Docking Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endomembrane System Chloride Channel Inhibitor Activity Vesicle Docking Vesicle Organization Vesicle-mediated Transport Endoplasmic Reticulum Organization Plasma Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane External Side Of Plasma Membrane Establishment Of Protein Localization Cellular Localization Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex FFAT Motif Binding Lipid Biosynthetic Process Zymogen Granule Membrane Endoplasmic Reticulum-autophagosome Adaptor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Vesicle Positive Regulation Of Mitochondrial Fission Synaptic Vesicle COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization	Immune System Process Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response Inflammatory Response Immune Effector Process Regulation Of Immune Response Leukocyte Degranulation Regulation Of Immune System Process Positive Regulation Of Monocyte Chemotactic Protein-1 Production Fc Receptor Signaling Pathway Immune Response Acute Inflammatory Response Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Positive Regulation Of Immune System Process Response To External Biotic Stimulus Regulation Of Cell Population Proliferation Regulation Of Interleukin-8 Production Regulation Of Superoxide Metabolic Process Cellular Response To Molecule Of Fungal Origin Membrane Extracellular Region Fc-gamma Receptor Signaling Pathway Exocytosis Response To Molecule Of Fungal Origin Regulation Of Phagocytosis Regulated Exocytosis Plasma Membrane Acute-phase Response Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Complement Component C1q Complex Binding Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Neutrophil Differentiation Response To Other Organism Positive Regulation Of Myeloid Cell Apoptotic Process Defense Response To Fungus Cell Activation Virion Binding Positive Regulation Of Immune Response Response To Fungus Positive Regulation Of Interleukin-8 Production Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Tumor Necrosis Factor Production Carbohydrate Binding Negative Regulation Of Inflammatory Response Defense Response To Symbiont
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