JAGN1 and SMIM19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		JAGN1	SMIM19
Description		jagunal vesicle mediated transporter 1	small integral membrane protein 19
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Immune System Process Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Response To Glucose Protein Transport Vesicle-mediated Transport Insulin Secretion Neutrophil Differentiation Response To Endoplasmic Reticulum Stress Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Insulin Metabolic Process Neutrophil Migration
Pathways
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Brain morphology (MOSTest) ( 32665545) Gut microbiota (functional units) ( 27694959) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin concentration ( 28453575)
Interacting Genes		128 interacting genes: AGPAT4 APP AQP6 ARL13B ARLN BCL2L13 BET1 BMP10 BNIP1 BNIP3 BSND BTNL9 CALHM6 CCL4L2 CD79A CDIPT CERS4 CGRRF1 CLDN7 CLEC12B CLEC4D CLEC7A CMTM5 COX20 CREB3L1 CYBC1 CYP4F2 DNAJC30 EBP EDA2R EHHADH ELOVL4 ERG28 ERGIC3 F11R FAM177A1 FAM209A FCGR1A FCRL2 FCRL4 FDFT1 FIS1 FKBP8 FNDC9 FRMD3 FXYD6 GIMAP1 GIMAP5 GJB5 GOLM1 GOSR2 GP2 GPR152 GPR37L1 HMOX1 HSD17B13 HTATIP2 ICMT IER3IP1 IFNGR2 IL3RA KASH5 KCNA1 KIR2DL3 KIR3DL3 LEMD1 LHFPL5 LMNA LPAR3 MFF MRM3 MTIF3 NINJ2 NRG1 OTULINL PDZK1IP1 PLP1 PLPP2 PSCA RETREG3 RTP2 SACM1L SAR1A SCD SEC22B SERP1 SLAMF6 SLC10A6 SLC16A2 SLC23A2 SLC34A2 SMAGP SMIM1 SMIM19 SSMEM1 STOML3 STX1A STX3 STX5 STX7 STX8 TECR TIMM23 TMEM100 TMEM106C TMEM120B TMEM128 TMEM14B TMEM207 TMEM237 TMEM242 TMEM243 TMEM52B TMEM65 TMIE TNFSF14 TREX1 TSNARE1 UBE2J1 USE1 VAMP2 VAMP5 VAPA VAPB VKORC1 VMA12 VSIG4 VTI1B	5 interacting genes: ASPH GET3 JAGN1 UBQLN1 UBQLN2
Entrez ID		84522	114926
HPRD ID		13749	14005
Ensembl ID		ENSG00000171135	ENSG00000176209
Uniprot IDs		Q8N5M9	Q96E16
PDB IDs		6WVD
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNAP Receptor Activity Endoplasmic Reticulum SNARE Complex Membrane Fusion Organelle Membrane Fusion SNARE Binding Protein Binding Vesicle Fusion Organelle Fusion Organelle Localization By Membrane Tethering Membrane Organization Golgi Vesicle Transport Membrane Docking Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endomembrane System Chloride Channel Inhibitor Activity Vesicle Docking Vesicle Organization Vesicle-mediated Transport Endoplasmic Reticulum Organization Plasma Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane External Side Of Plasma Membrane Establishment Of Protein Localization Cellular Localization Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex FFAT Motif Binding Lipid Biosynthetic Process Zymogen Granule Membrane Endoplasmic Reticulum-autophagosome Adaptor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Vesicle Positive Regulation Of Mitochondrial Fission Synaptic Vesicle COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization	Positive Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Dioxygenase Activity Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Negative Regulation Of Transport Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Autophagosome Organization Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Indoleamine 2,3-dioxygenase Activity Endoplasmic Reticulum GET Complex Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Tryptophan 2,3-dioxygenase Activity Negative Regulation Of Clathrin-dependent Endocytosis Vacuole Organization Activation Of Store-operated Calcium Channel Activity Granulocyte Colony-stimulating Factor Signaling Pathway L-tryptophan Catabolic Process To Kynurenine Positive Regulation Of Protein Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Protein Catabolic Process Regulation Of Calcium Ion Transport Cortical Endoplasmic Reticulum Neutrophil Differentiation Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus 'de Novo' NAD+ Biosynthetic Process From L-tryptophan L-tryptophan Catabolic Process Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Regulation Of Monoatomic Cation Transmembrane Transport Kynurenine Metabolic Process Endoplasmic Reticulum Membrane
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