MCM8 and MCM4

Number of citations of the paper that reports this interaction (PubMedID 12771218)
35

Data Source:
HPRD (in vivo)

		MCM8	MCM4
Description		minichromosome maintenance 8 homologous recombination repair factor	minichromosome maintenance complex component 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome MCM Complex MCM8-MCM9 Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MCM Complex CMG Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Damage Response Female Gamete Generation Recombinational Interstrand Cross-link Repair Male Gamete Generation Protein Stabilization Mismatch Repair Involved In Maintenance Of Fidelity Involved In DNA-dependent DNA Replication Protein Localization To Chromatin	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication Initiation
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Estradiol levels ( 34255042) HIV-1 viral setpoint ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201 26414677 29773799) Preeclampsia ( 23551011) Uterine fibroids ( 30194396 31649266)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		4 interacting genes: FEM1C MCM4 MCM6 MCM7	28 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 CEBPA DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 SSRP1 SUMO2 SUPT16H TLX2 UBE3A
Entrez ID		84515	4173
HPRD ID		12186	09094
Ensembl ID		ENSG00000125885	ENSG00000104738
Uniprot IDs		B4DN82 Q9UJA3	B3KMX0 B4DLA6 P33991
PDB IDs		6L0O 7DP3 7WI7 7YOX 8S91 8S92 8S94	6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation DNA Helicase Activity Single-stranded DNA Binding Regulation Of DNA Replication Helicase Activity Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Replication DNA Strand Elongation Involved In DNA Replication Chromosome, Telomeric Region Single-stranded DNA Helicase Activity DNA Strand Elongation Double-strand Break Repair DNA Recombination ATP Hydrolysis Activity Regulation Of DNA Metabolic Process DNA Repair Chromosome DNA Metabolic Process DNA Damage Response Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Mitotic DNA Replication Initiation Nuclear DNA Replication ATP Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Nucleoplasm Cellular Response To Stress Hydrolase Activity Nucleotide Binding Cul2-RING Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Macromolecule Metabolic Process DNA Binding Nucleobase-containing Compound Metabolic Process DNA-templated DNA Replication Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Cellular Response To Xenobiotic Stimulus Response To Stress Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Complex	DNA Replication DNA Metabolic Process DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Replication Nucleic Acid Metabolic Process Origin Recognition Complex Chromosome, Telomeric Region Nucleobase-containing Compound Metabolic Process MCM Complex Nucleoplasm Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding DNA Repair Nucleus Macromolecule Metabolic Process DNA Damage Response Regulation Of DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome CMG Complex Double-strand Break Repair Cellular Response To Stress Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated DNA Replication DNA Binding Single-stranded DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination DNA Recombination Recombinational Repair G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Chromatin Binding ATP Binding Single-stranded DNA Binding Regulation Of Nuclear Cell Cycle DNA Replication DNA-templated DNA Replication Helicase Activity Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Regulation Of Primary Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Nucleotide Binding Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex
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