MCM8

Gene Name		minichromosome maintenance complex component 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm MCM8-MCM9 Complex
	Molecular Function	DNA Binding Helicase Activity Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Female Gamete Generation Male Gamete Generation
Pathways		G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin DNA strand elongation Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS		HIV-1 control ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201) Preeclampsia ( 23551011)
Protein-protein Interactions		3 interactors: MCM4 MCM6 MCM7
Entrez ID		84515
HPRD ID		12186
Ensembl ID		ENSG00000125885
Uniprot IDs		B4DN82 Q9UJA3
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation DNA Duplex Unwinding DNA Geometric Change DNA-dependent DNA Replication G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication DNA Conformation Change Mitotic Cell Cycle Process Mitotic Cell Cycle Chromosome Organization Cell Cycle Process DNA Metabolic Process Cell Cycle Organelle Organization Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process
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